Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats

Table 1 Effect of COS on changes of DNA damage in pancreatic β cells induced by STZ (n = 9, mean ± SD)

Group	Concentration (mg/L)	Tail length (&mgr;m)	Tail DNA (%)	Tail moment	Olive tail moment
Control		7.64 ± 6.92b	0.83 ± 1.16b	0.13 ± 0.24b	0.32 ± 0.47b
STZ		80.50 ± 31.72	29.93 ± 15.93	28.01 ± 22.34	25.73 ± 18.52
COS	10	49.90 ± 33.83a	28.41 ± 23.35	20.69 ± 21.67	17.10 ± 14.73
	100	34.67 ± 41.72b	19.77 ± 24.28	13.86 ± 20.36	11.15 ± 15.40a
	500	23.00 ± 20.79b	6.56 ± 7.57b	2.90 ± 4.12b	3.64 ± 4.54b
	1000	51.00 ± 15.44a	20.14 ± 10.51	11.48 ± 9.42	13.06 ± 6.61a

^aP < 0.05,

^bP < 0.01 vs DM group.

Table 2 Effect of COS on changes of serum antioxidant in STZ-induced diabetes in rats (n = 9, mean ± SD)

Group	Concentration (mg/kg)	T-AOC (U/mL)	GPH-PX (U/mL)	MDA (nmol/mL)	SOD (U/mL)
Control		12.10 ± 2.58b	468.61 ± 4.35	6.21 ± 0.53b	182.51 ± 15.73b
DM		5.94 ± 1.70	467.363 ± 4.17	13.82 ± 1.69	116.67 ± 2.19
COS-H	1500	10.02 ± 1.34b	458.70 ± 4.47	6.03 ± 0.93b	136.89 ± 13.66
COS-M	500	7.49 ± 1.03a	461.82 ± 10.20	6.88 ± 1.08b	141.65 ± 11.13a
COS-L	250	6.96 ± 2.45a	464.76 ± 8.79	7.2 ± 1.59b	152.84 ± 13.52b

^aP < 0.05,

^bP < 0.01 vs DM group.