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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Mar 21, 2009; 15(11): 1339-1345
Published online Mar 21, 2009. doi: 10.3748/wjg.15.1339
Published online Mar 21, 2009. doi: 10.3748/wjg.15.1339
Table 1 Effect of COS on changes of DNA damage in pancreatic β cells induced by STZ (n = 9, mean ± SD)
Group | Concentration (mg/L) | Tail length (&mgr;m) | Tail DNA (%) | Tail moment | Olive tail moment |
Control | 7.64 ± 6.92b | 0.83 ± 1.16b | 0.13 ± 0.24b | 0.32 ± 0.47b | |
STZ | 80.50 ± 31.72 | 29.93 ± 15.93 | 28.01 ± 22.34 | 25.73 ± 18.52 | |
COS | 10 | 49.90 ± 33.83a | 28.41 ± 23.35 | 20.69 ± 21.67 | 17.10 ± 14.73 |
100 | 34.67 ± 41.72b | 19.77 ± 24.28 | 13.86 ± 20.36 | 11.15 ± 15.40a | |
500 | 23.00 ± 20.79b | 6.56 ± 7.57b | 2.90 ± 4.12b | 3.64 ± 4.54b | |
1000 | 51.00 ± 15.44a | 20.14 ± 10.51 | 11.48 ± 9.42 | 13.06 ± 6.61a |
Table 2 Effect of COS on changes of serum antioxidant in STZ-induced diabetes in rats (n = 9, mean ± SD)
Group | Concentration (mg/kg) | T-AOC (U/mL) | GPH-PX (U/mL) | MDA (nmol/mL) | SOD (U/mL) |
Control | 12.10 ± 2.58b | 468.61 ± 4.35 | 6.21 ± 0.53b | 182.51 ± 15.73b | |
DM | 5.94 ± 1.70 | 467.363 ± 4.17 | 13.82 ± 1.69 | 116.67 ± 2.19 | |
COS-H | 1500 | 10.02 ± 1.34b | 458.70 ± 4.47 | 6.03 ± 0.93b | 136.89 ± 13.66 |
COS-M | 500 | 7.49 ± 1.03a | 461.82 ± 10.20 | 6.88 ± 1.08b | 141.65 ± 11.13a |
COS-L | 250 | 6.96 ± 2.45a | 464.76 ± 8.79 | 7.2 ± 1.59b | 152.84 ± 13.52b |
- Citation: Yuan WP, Liu B, Liu CH, Wang XJ, Zhang MS, Meng XM, Xia XK. Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats. World J Gastroenterol 2009; 15(11): 1339-1345
- URL: https://www.wjgnet.com/1007-9327/full/v15/i11/1339.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.1339