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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Mar 7, 2008; 14(9): 1389-1393
Published online Mar 7, 2008. doi: 10.3748/wjg.14.1389
Published online Mar 7, 2008. doi: 10.3748/wjg.14.1389
Table 1 Clinical data of patients admitted to ICU with sepsis
| No | Age | Sex | Diagnosis | Cause of hospitalization | APACHE II | Cultured sample | Infective agent |
| 1 | 58 | Male | Respiratory infection | ARD | 17 | Blood | Klebsiella |
| 2 | 70 | Male | Respiratory infection | ARD | 15 | Blood | Klebsiella |
| 3 | 84 | Male | Respiratory infection | Heart failure | 17 | Respiratory (BAL) | Enterobacter |
| 4 | 57 | Male | Respiratory infection | AMI | 23 | Venous catheter | Klebsiella |
| 5 | 50 | Male | Soft tissue infection | Soft tissue infection | 20 | Skin | Staphylococcus epidermidis |
| 6 | 74 | Male | Intra-abdominal sepsis | Peritonitis | 29 | Blood | Enterobacter |
| 7 | 45 | Female | Intra-abdominal sepsis | Peritonitis | 21 | Venous catheter | Klebsiella |
| 8 | 74 | Female | Peritonitis | Peritonitis | 30 | Midstream urine sample | Candida albicans |
| 9 | 86 | Male | Sepsis | Sepsis | 37 | Venous catheter | Pseudomonas |
| 10 | 75 | Male | Respiratory infection | ARD | 27 | Blood | Pseudomonas |
| 11 | 33 | Male | Soft tissue infection | Burn injury | 7 | Blood | Acinetobacter |
| 12 | 69 | Male | Peritonitis | Peritonitis | 17 | Blood | Klebsiella |
| 13 | 72 | Female | Respiratory infection | ARD | 15 | Blood | Klebsiella |
| 14 | 70 | Male | Respiratory infection | AMI | 26 | Venous catheter | Klebsiella |
| 15 | 77 | Male | Respiratory infection | Aneurysm | 20 | Respiratory (BAL) | Candida |
Table 2 Clinical and laboratory parameters in patients who died from sepsis at entry and before death (Data are presented as median, range)
| Variable | Initial | Final | P-value |
| Heart rate (/min) | 88 (50-150) | 86 (76-140) | NS |
| Systolic blood pressure (mmHg) | 130 (70-180) | 110 (60-150) | 0.017 |
| Diastolic blood pressure (mmHg) | 70 (45-80) | 50 (40-80) | 0.018 |
| PO2 (mmHg) | 154 (50-579) | 81 (45-120.8) | 0.008 |
| PCO2 (mmHg) | 42 (23-138) | 38 (28.1-81) | NS |
| pH | 7.36 (7.14-7.46) | 7.33 (6.93-7.46) | NS |
| HCO3 (mmol/L) | 24 (11.3-31.2) | 18.5 (11-32.4) | NS |
| Bilirubin (&mgr;mol/L) | 17.1 (6.84-107.73) | 23.94 (8.55-356.13) | NS |
| AST (nKat/L) | 600 (230-2230) | 650 (150-4160) | NS |
| ALT (nKat/L) | 680 (150-4170) | 450 (100-2730) | NS |
| ALP (nKat/L) | 1080 (45-3550) | 2250 (930-4630) | 0.019 |
| γGT (nKat/L) | 850 (180-6700) | 2030 (630-5720) | NS |
Table 3 Clinical and laboratory parameters according to morphologically determined apoptosis in liver
| Parameter | Liver apoptosis | P-value | |
| Yes (n = 10) | No (n = 5) | ||
| APACHE II | 17 (7-26) | 18.5 (15-37) | NS |
| Heart rate (min) | 86 (76-124) | 93 (76-140) | NS |
| Systolic blood pressure (mmHg) | 105 (60-150) | 112.5 (85-145) | NS |
| Diastolic blood pressure (mmHg) | 50 (40-80) | 55 (50-65) | NS |
| PO2 (mmHg) | 89.5 (49-120.8) | 77.5 (45-110) | NS |
| pH | 7.34 (7.09-7.46) | 7.29 (6.93-7.38) | NS |
| Bilirubin (mmol/L) | 23.94 (11.97-356.2) | 42.7 (8.55-140.22) | NS |
| Direct bilirubin (mmol/L) | 17.442 (5.13-230.166) | 53.1 (10.26-136.166) | NS |
| AST (nKat/L) | 683.47 (433.42-3717) | 516.8 (216.7-467) | NS |
| ALT (nKat/L) | 733.48 (100-2733.9) | 433.4 (250.1-1150.2) | NS |
| γGT (nKat/L) | 2283.8 (1083.6-5717) | 1467 (633.5-4500) | NS |
| ALP (nKat/L) | 2300.5 (1700.3-4634.3) | 1967.1 (933.2-3133) | NS |
- Citation: Koskinas J, Gomatos IP, Tiniakos DG, Memos N, Boutsikou M, Garatzioti A, Archimandritis A, Betrosian A. Liver histology in ICU patients dying from sepsis: A clinico-pathological study. World J Gastroenterol 2008; 14(9): 1389-1393
- URL: https://www.wjgnet.com/1007-9327/full/v14/i9/1389.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.1389