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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Feb 28, 2008; 14(8): 1280-1285
Published online Feb 28, 2008. doi: 10.3748/wjg.14.1280
Published online Feb 28, 2008. doi: 10.3748/wjg.14.1280
Table 1 Demographic characteristics of recipients
Gender | n (%) |
Male | 129 (86.0) |
Female | 21 (14.0) |
Median age (range) | 51 (28-68) |
Hepatitis B | 150 (100) |
Child’s score | |
A (5-6) | 89 (59.3) |
B (7-9) | 46 (30.7) |
C (10-15) | 15 (10.0) |
MELD score | |
≤ 18 | 132 (88.0) |
> 18 | 18 (12.0) |
Table 2 Pretransplant biochemical features of recipients
Variables | mean ± SD | Min value | Max value |
Hb (g/dL) | 12.23 ± 2.62 | 4.3 | 18.7 |
PLT (× 109) | 131.4 ± 86.0 | 17 | 569 |
Urea (mmol/L) | 4.90 ± 2.01 | 2.4 | 16.2 |
Crea (mg/dL) | 1.06 ± 0.10 | 1 | 1.44 |
ALB (g/dL) | 3.79 ± 0.68 | 2.01 | 5.28 |
TB (mg/dL) | 26.8 ± 37.4 | 10 | 260.2 |
AKP (u/L) | 160.51 ± 130.97 | 18 | 779 |
GGT (u/L) | 215.34 ± 255.40 | 24 | 1630 |
AST (u/L) | 89.83 ± 76.23 | 19 | 421 |
ALT (u/L) | 101.49 ± 99.19 | 12 | 486 |
INR for PT | 1.25 ± 0.24 | 1 | 2.16 |
AFP (&mgr;g/L) | 426.65 ± 393.91 | 1.97 | 3000 |
Na+ ( mEq/L) | 137.12 ± 5.33 | 114.2 | 150.3 |
Table 3 HCC-related features of recipients
Variable | Code | Frequency | Proportion (%) | |
History of | Present | 1 | 15 | 10 |
hepatectomy | Absent | 0 | 135 | 90 |
for HCC | ||||
Tumor diameter | 1: < 5 cm | 1 | 65 | 43.3 |
2: 5 cm- | 2 | 58 | 38.7 | |
Reference: > 10 cm | 3 | 27 | 18 | |
Tumor nodule | Nodule 1: one | 1 | 93 | 62 |
Nodule 2: two | 2 | 31 | 20.7 | |
Reference: > two | 3 | 26 | 17.3 | |
Vascular invasion | Present | 1 | 20 | 13.3 |
Absent | 0 | 130 | 86.7 | |
Intrahepatic tumor | Present Absent | 1 | 33 | 22 |
dissemination | 0 | 117 | 78 | |
Perihepatic | Present | 1 | 10 | 6.7 |
lymphadenectasis | Absent | 0 | 140 | 93.3 |
Table 4 Univariate Cox analysis of parameters
Variable | Regression coefficient | Regression coefficient SE | Wald | P-value | Expβ |
Hb (loge) | -0.510 | 0.510 | 0.997 | 0.318 | 0.601 |
PLT (loge) | 0.060 | 0.230 | 0.068 | 0.795 | 1.062 |
Urea (loge) | 0.024 | 0.457 | 0.003 | 0.958 | 1.025 |
Crea (loge) | -0.427 | 1.671 | 0.065 | 0.798 | 0.652 |
ALB (loge) | -2.056 | 0.695 | 8.758 | 0.003 | 0.128 |
TB (loge) | 0.277 | 0.165 | 2.838 | 0.092 | 1.320 |
AKP (loge) | 0.581 | 0.214 | 7.328 | 0.007 | 1.787 |
GGT (loge) | 0.254 | 0.148 | 2.930 | 0.087 | 1.289 |
AST (loge) | 0.535 | 0.202 | 6.987 | 0.008 | 1.707 |
ALT (loge) | -0.172 | 0.178 | 0.926 | 0.336 | 0.842 |
INR (loge) | -0.065 | 0.818 | 0.006 | 0.937 | 0.937 |
AFP (loge) | 0.104 | 0.071 | 2.742 | 0.098 | 1.109 |
Na+ (loge) | -7.161 | 3.144 | 5.190 | 0.023 | 0.001 |
History of hepatectomy | -0.160 | 0.474 | 0.115 | 0.735 | 0.852 |
Tumor diameter | 6.245 | 0.089 | |||
1 | -1.057 | 0.505 | 4.385 | 0.036 | 0.347 |
2 | 0.278 | 0.359 | 0.603 | 0.437 | 1.321 |
Tumor nodule | 5.410 | 0.067 | |||
1 | -0.391 | 0.364 | 1.153 | 0.283 | 0.677 |
2 | 0.419 | 0.419 | 1.000 | 0.317 | 1.520 |
Vascular invasion | 0.368 | 0.300 | 1.503 | 0.22 | 1.445 |
Intrahepatic tumor dissemination | 0.190 | 0.345 | 0.305 | 0.581 | 1.210 |
Perihepatic lymphadenectasis | 0.583 | 0.526 | 1.226 | 0.268 | 1.791 |
Table 5 Multivariate Cox assessment of risk factors associated with post-LT mortality
Variable | Regression coefficient | Regression coefficient SE | Wald | P-value | Expβ |
AKP (loge) | 0.663 | 0.222 | 8.917 | 0.003 | 1.941 |
AFP (loge) | 0.122 | 0.074 | 4.042 | 0.048 | 1.130 |
Na+ (loge) | -8.755 | 3.252 | 7.247 | 0.007 | 0.000 |
Tumor nodule | 8.189 | 0.017 | 0.532 | ||
1 | -0.631 | 0.373 | 4.265 | 0.041 |
- Citation: Zhang M, Li B, Yan LN, Yin F, Wen TF, Zeng Y, Zhao JC, Ma YK. Development of a survival evaluation model for liver transplant recipients with hepatocellular carcinoma secondary to hepatitis B. World J Gastroenterol 2008; 14(8): 1280-1285
- URL: https://www.wjgnet.com/1007-9327/full/v14/i8/1280.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.1280