Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006

Table 1 Patient details and HCV genotype distribution in the overall population, in the Centre Pénitentiaire of Luxembourg (CPL) and in the general population

Variable	Overall	CPL	General
n (%)	802 (100)	228 (28.4)	574 (71.6)
Sex ratio	2.2	17.8	1.44
Age (% less than 40 yr)	49.6	77.6	38.5
Genotype
1	428 (53.4)	102 (44.7)	326 (56.8)
2	38 (4.7)	8 (3.5)	30 (5.2)
3	264 (33)	106 (46.5)	158 (27.5)
4	67 (8.3)	12 (5.3)	55 (9.6)
5	5 (0.6)	0	5 (0.9)

Table 2 Transmission risk factors in the overall population, in the Centre Pénitentiaire of Luxembourg (CPL) and in the general population

Risk factor	Overall	CPL	General
n (%)	437 (100)	104 (23.8)	333 (76.2)
IVDU	312 (71.4)	98 (94.2)	214 (64.3)
Medical-related	77 (17.6)	4 (3.8)	73 (21.9)
Sexual	35 (8)	0	35 (10.5)
Other	13 (3)	2 (2)	11 (3.3)

Table 3 Associations between genotype and transmission risk factors for the overall population

Risk factor	IVDU	Medical-related
Odds ratios (OR)
Genotype 1	0.50 (0.33 to 0.77, P = 0.0016)	2.42 (1.43 to 4.05, P = 0.0008)
Genotype 3	4.84 (2.86 to 8.25, P < 0.0001)	0.17 (0.09 to 0.35, P < 0.0001)
MH adjusted OR1
Genotype 1	0.49 (0.30 to 0.84, P = 0.0084)	2.34 (1.35 to 4.06, P = 0.0025)
Genotype 3	4.54 (1.60 to 12.70, P = 0.0043)	0.21 (0.07 to 0.64, P = 0.0064)
MH adjusted OR2
Genotype 1	0.55 (0.35 to 0.85, P = 0.0081)	2.24 (1.31 to 3.84, P = 0.0033)
Genotype 3	4.28 (2.42 to 7.57, P < 0.0001)	0.20 (0.09 to 0.42, P < 0.0001)

Odds ratio with confidence intervals 95%.

¹Mantel-Haenszel odds ratio adjusted for age and gender;

²Mantel-Haenszel odds ratio adjusted for population type.