MLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families

Table 1 Characteristics of 18 probands with MSI-H

Case	Gender	Age (yr)	Criteria	MSI	MLH1/MSH2/MSH6 mutation study
H21	M	38	AC	MSI-H	NM
H22	M	46	AC	MSI-H	NM
H28	F	30	AC	MSI-H	NM
H29	F	37	AC	MSI-H	NM
H32	M	51	AC	MSI-H	NM
H42	M	65	AC	MSI-H	NM
H46	M	48	AC	MSI-H	NM
H57	F	47	ACII	MSI-H	NM
H63	F	47	AC	MSI-H	NM
H10	M	41	JC	MSI-H	NM
H12	F	50	JC	MSI-H	NM
H41	M	46	JC	MSI-H	NM
H55	M	49	JC	MSI-H	NM
H7	M	38	BG	MSI-H	NM
H8	M	43	BG	MSI-H	NM
H30	M	48	BG	MSI-H	NM
H35	F	38	BG	MSI-H	NM
H51	F	27	BG	MSI-H	NM

AC: Amsterdam criteria; JC: Japanese criteria; BG: Bethesda guidelines; MSI-H: High microsatellite instability; NM: No mutation.

Table 2 Characteristics of 6 probands with MSS

Case	Gender	Age (yr)	Criteria	MSI	MLH1/MSH2/MSH6 mutation study
H16	F	44	JC	MSS	NM
H20	F	54	BG	MSS	NM
H44	F	39	BG	MSS	NM
H48	M	28	BG	MSS	NM
H50	M	55	BG	MSS	NM
H54	M	43	BG	MSS	NM

JC: Japanese criteria; BG: Bethesda guidelines; MSS: Microsatellite stability; NM: No mutation.