Effect of mucin production on survival in colorectal cancer: A case-control study

Table 1 Demographic data of patients with MCRC and controls

	MCRC (%), n = 35	NMCRC (%), n = 35	P
Mean age	56.8 (22-83)	56.7 (28-81)
Gender (M:F)	20:15	20:15
Comorbid conditions
Heart disease	4 (11.4)	2 (5.7)	0.673
Diabetes mellitus	2 (5.7)	2 (5.7)	1.000
Hypertension	3 (8.6)	9 (25.7)	0.110
Other cancer	2 (5.7)	1 (2.9 )
Family history
Colon cancer	4 (11.4)	2 (5.7)	0.673
Other cancer	8 (22.9)	11 (28.6)	0.785

Table 2 Distribution of the tumor by location in the colon

	MCRC (%), n = 35	NMCRC (%), n = 35
Location
Right colon	8 (22.8)	7 (20)
Transverse colon	2 (5.7)	1 (2.9)
Left colon	14 (40)	16 (45.7)
Rectum/Rectosigmoid	10 (28.6)	10 (28.6)
Grade
Poor	10 (28.6)	3 (8.6)
Moderate	16 (45.7)	26 (74.3)
Well	6 (17.1)	3 (8.6)
Missing	3 (8.6)	3 (8.6)
Stage
I	2 (5.7)	2 (5.7)
II	12 (34.3)	12 (34.3)
III	14 (40)	13 (37.1)
IV	7 (20)	8 (22.8)

Table 3 Colorectal recurrence and patterns of metastasis in patients with MCRC and controls

	MCRC (%), n = 35	NMCRC (%), n = 35
Colorectal recurrence	6 (17)	7 (20)
Metastasis on presentation	5 (14.3)	4 (11.4)
Metastasis on follow up	7 (20)	14 (40)
Sites involved by metastasis
Liver	8 (22.8)	12 (34.3)
Lung	4 (11.4)	4 (11.4)
Bone	2 (5.7)	1 (2.9)
Brain	1 (2.9)	2 (5.7)
Other	7 (20)	6 (17.1)
Lymph node involvement	13 (37.1)	13 (37.1)

Table 4 Treatment offered to patients with MCRC and controls

	MCRC (%), n = 35	NMCRC (%), n = 35
Treatment
Surgery	35 (100)	35 (100)
Chemotherapy	20 (57.1)	19 (54.3)
Neoadjuvant	5 (14.3)	3 (8.6)
Adjuvant	15 (42.9)	16 (45.7)
Type	5-Fu + leucovorin ± oxaliplatin	5-Fu + leucovorin ± oxaliplatin
Radiotherapy	11 (31.4)	8 (22.9)

Table 5 Studies matching mucinous cases to non-mucinous controls

	Case: control	Matched for	Survival in MCRC vs NMCRC	P
Symonds et al[14]	120/120	Age, sex, stage	Decreased	Significant
Connelly et al[16]	60/60	Stage	Same	NS
Green et al[13]	52/343	Stage	Same	NS
Consorti et al[3]	29/54	Age, sex, location, stage	Decreased	NS
Kang et al[8]	16 991/146 115	Age, grade, stage, location	Same	NS
Farhat	35/35	Age, sex, stage	Decreased	NS

NS: Not significant.