Mouse models in liver cancer research: A review of current literature

Table 1 Transgenic mouse models for HCC

Transgene	Promoter	Mouse strain	Percentage HCCs	Reference
c-myc	Alb	C57BL/6 × CBA/J	65% in males at 20 mo	40
TGF-α	MT	CD1	50% in males > 12 mo	77, 78
c-myc/TGF-α	Alb, MT	C57BL/6 × CBA/J × CD1	100% in males at 8 mo	40
SV40 T-Ag	ATIII	C57BL/6 × DBA2	100% at 8 mo	36
E2F-1	Alb	C57BL/6 × CBA/J	33%-60% at 12 mo	79, 80
c-myc/E2F-1	Alb	C57BL/6 × CBA/J	100% at 9 mo	80