Study on protecting effects of Baicalin and Octreotide on hepatic injury in rats with severe acute pancreatitis

doi:10.3748/wjg.14.6551

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2008; 14(42): 6551-6559
Published online Nov 14, 2008. doi: 10.3748/wjg.14.6551

Table 1 Comparison of different pathological indexes [M (Q_R)]

Indexes	Sham-operated group			Model control group			Baicalin treated group			Octreotide treated group
Indexes	3 h	6 h	12 h	3 h	6 h	12 h	3 h	6 h	12 h	3 h	6 h	12 h
Pathological score of liver	0.0	0.0	0.0	2.0¹	3.0¹	3.0¹	1.0¹	2.0¹	2.0¹^c	2.0¹	2.0¹	2.0¹^c
Pathological score of liver	(0.0)	(0.0)	(0.0)	(1.0)	(1.0)	(0.25)	(2.0)	(2.0)	(2.0)	(2.0)	(2.0)	(1.0)
Pathological score of pancreas	0.0	0.0	0.0	8.0¹	9.0¹	10.5¹	7.0¹	7.0¹	9.0¹^d	7.0¹	6.0¹^d	8.0¹^d
Pathological score of pancreas	(1.0)	(1.0)	(1.0)	(2.0)	(3.0)	(1.5)	(1.5)	(3.0)	(4.0)	(2.0)	(2.0)	(2.0)
Bax	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0^a^c	0.0	0.0	0.0^a	0.0^b
Bax	(0.0)	(0.0)	(0.0)	(1.0)	(0.0)	(0.0)	(0.5)	(1.0)	(0.0)	(1.0)	(1.0)	(1.0)
Bcl-2	0.0	0.0	0.0	0.0^a	3.0^a	0.0^a	0.0^a^e	0.0^c	0.0^c	0.0^c	0.0^c	0.0^c
Bcl-2	(0.0)	(0.0)	(0.0)	(1.0)	(2.5)	(2.0)	(1.0)	(0.0)	(0.0)	(0.0)	(0.0)	(0.0)
Caspase-3	0.0	0.0	0.0	0.0^a	0.0^a	0.0^a	0.0^b	0.0^b	1.0^b^c	1.0^a	0.0^a	0.0^a
Caspase-3	(0.0)	(0.0)	(0.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)
Apoptosis indexes	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.02^a^d	0.00	0.00	0.02^a^c	0.00^a^c
Apoptosis indexes	(0.00)	(0.00)	(0.00)	(0.00)	(0.00)	(0.00)	(0.00)	(0.10)	(0.00)	(0.04)	(0.04)	(0.06)

¹P < 0.001, vs sham-operated group.

^aP < 0.05,

^bP < 0.01, vs sham-operated group;

^cP < 0.05,

^dP < 0.01, vs model control group;

^eP < 0.05, vs octreotide treated group.

Table 2 Comparison of ALT, AST contents in blood [M (Q_R)]

Indexes	Sham-operated group			Model control group			Baicalin treated group			Octreotide treated group
Indexes	3 h	6 h	12 h	3 h	6 h	12 h	3 h	6 h	12 h	3 h	6 h	12 h
ALT	28 (12)	29 (10)	35 (9)	332¹ (140)	623¹ (193)	641¹ (163)	102¹²^d (99)	150¹² (69)	178¹²^c (111)	208¹² (128)	158¹² (57)	226¹² (50)
AST	130 (37)	142 (26)	158 (29)	528¹ (270)	975¹ (242)	987¹ (230)	221¹²³ (205)	306¹²^c (225)	472¹² (114)	423¹^a (229)	420¹² (163)	513¹² (258)

¹P < 0.001, vs sham-operated group;

²P < 0.001, vs model control group;

³P < 0.001, vs octreotide treated group.

^aP < 0.05, vs model control group;

^cP < 0.05,

^dP < 0.01, vs octreotide treated group.

Citation: Zhang XP, Zhang J, Ren Z, Feng GH, Zhu W, Cai Y, Yang QJ, Ju TF, Xie Q, Yuan WQ. Study on protecting effects of Baicalin and Octreotide on hepatic injury in rats with severe acute pancreatitis. World J Gastroenterol 2008; 14(42): 6551-6559
URL: https://www.wjgnet.com/1007-9327/full/v14/i42/6551.htm
DOI: https://dx.doi.org/10.3748/wjg.14.6551