Relation of atrophic gastritis with Helicobacter pylori-CagA+ and interleukin-1 gene polymorphisms

Table 1 Sex, age and pepsinogen levels according to histopathological diagnosis

	Sex (M/F) (n = 155/324)	Age (yr), mean (95% CI)	PGI (mg/L), mean (95% CI)	PGI/PGII, mean (95% CI)
Normal	9/12	38 (30.7-45.7)	39.7 (27.9-51.5)	4.3 (3.3-5.4)
NAG	104/225	45 (43.2-46.6)	53.1 (49.4-56.9)	3.3 (3.1-3.6)
AAG	26/67	50 (47.0-52.8)	60.2 (52.9-67.5)	3.3 (2.9-3.7)
ABG	16/20	53 (48.2-57.6)	36.1 (26.6-45.5)1	1.9 (1.5-2.4)1

¹P≤ 0.001, ABG vs the rest.

Table 2 OR with 95% CI for the association between atrophic gastritis and risk factors in dyspeptic H pylori-status⁺ patients¹

	Atrophic gastritis in antrum (AAG)			Atrophic gastritis in body (ABG)
	OR	95% CI	P	OR	95% CI	P
Age > 50 yr	1.6	0.8-3.0	0.2	2.8	1.0-7.7	0.04
Men	0.6	0.3-1.2	0.2	1.2	0.4-3.5	0.7
Overweight (BMI > 25.9)	0.7	0.3-1.2	0.2	0.8	0.3-2.0	0.6
Fruit consumption
0-1 times/wk	1.0			1.0
2-6 times/wk	0.4	0.2-0.8	0.01	1.4	0.4-4.6	0.6
More than 6 times/wk	0.3	0.2-0.7	0.00	0.7	0.2-2.6	0.6
Alcohol consumption
No consumption	1.0			1.0
Weekends or more	3.0	0.8-12	0.1	7.3	1.5-35.8	0.02
H pylori
CagA status+	4.1	1.9-9.0	0.000	1.2	0.4-3.5	0.7
IL-1B + 3954
T carriers vs CC	0.6	0.3-1.2	0.16	0.9	0.3-2.4	0.8
IL-1RN
2 carriers vs LL	1.4	0.8-2.6	0.3	1.3	0.5-3.5	0.6
PGI/PGII ≤ 3.4	1.4	0.7-2.8	0.3	4.9	1.1-22.5	0.04

¹Logistic regression, AAG and ABG vs non-atrophic gastritis.

Table 3 OR with 95% CI for the association between PGI and PGI/PGII and risk factors in dyspeptic H pylori-status⁺ patients¹

	PGI < 60μg/L			PGI/PGII < 3.4
	OR	95% CI	P	OR	95% CI	P
Age > 50 yr	1.1	0.6-1.8	0.8	1.6	1.0-2.7	0.07
Men	1.6	0.9-2.7	0.09	0.7	0.4-1.2	0.2
Overweight (BMI > 25.9)	1.0	0.6-1.7	0.9	0.6	0.4-1.0	0.04
Fruit consumption
0-1 times/wk	1.0			1.0
2-6 times/wk	0.6	0.3-1.2	0.1	1.6	0.9-2.8	0.1
More than 6 times/wk	1.3	0.7-2.4	0.4	1.3	0.7-2.4	0.4
Alcohol consumption
No consumption	1.0			1.0
Weekends or more	0.2	0.05-1.1	0.07	1.8	0.5-6.3	0.3
H pylori
CagA status+	2.5	1.4-4.3	0.002	1.8	1.1-3.0	0.03
IL-1B + 3954
T carriers vs CC	1.2	0.7-1.9	0.5	0.8	0.5-1.3	0.3
IL-1RN
2 carriers vs LL	1.6	1.0-2.7	0.06	0.9	0.6-1.4	0.3

¹Logistic regression, PGI < 60 μg/L vs PGI > 60 μg/L and PGI/PGII < 3.4 vs PGI/PGII > 3.4.

Table 4 Genotypic and allelic frequencies for the studied groups n (%)

	Normal	NAG	AAG	ABG
IL-1RN
L*L	11/17 (65)	124/253 (49)	33/76 (43)	13/25 (52)
L*2	6/17 (35)	107/253 (42)	31/76 (41)	8/25 (32)
2*2	0/17 (0)	22/253 (9)	12/76 (16)	4/25 (16)
Allelic freq. 2	0.16	0.27	0.29	0.28
IL-1B + 3954
CC	12/18 (66)	123/250 (49)	46/77 (60)	13/26 (50)
CT	5/18 (28)	121/250 (48)	30/77 (39)	13/26 (50)
TT	1/18 (6)	6/250 (3)	1/77 (1)	0/26 (0)
Allelic freq. T	0.22	0.26	0.20	0.24

Table 5 OR with 95% CI for the association between peptic ulcers and risk factors in dyspeptic H pylori-status⁺ patients¹

	Gastric ulcer			Duodenal ulcer
	OR	95% CI	P	OR	95% CI	P
Age > 50 yr	3.3	1.2-9.1	0.02	0.8	0.4-1.8	0.6
Men	0.3	0.9-1.3	0.1	3.2	1.5-7.2	0.004
Present smoker	1.2	0.3-4.7	0.8	2.4	1.0-5.6	0.04
H pylori
CagA status+	0.7	0.3-1.8	0.4	2.9	1.0-7.9	0.04
IL-1B + 3954
T carriers vs CC	1.2	0.5-3.2	0.7	0.9	0.4-1.9	0.8
IL-1RN
2 carriers vs LL	1.4	0.5-3.6	0.5	0.7	0.3-1.4	0.3

¹Logistic regression, Peptic ulcer vs no peptic ulcer.