Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats

Table 1 Physiological data over the study period

Variables	Groups	Pre-CPB	30 min after CPB	60 min after CPB	2 h after CPB
MAP (mmHg)	CPB	84.50 ± 7.05	62.14 ± 15.23ac	67.08 ± 19.12ac	72.18 ± 17.39ac
	Sham	86.33 ± 16.82	84.26 ± 14.55	85.45 ± 10.36	83.63 ± 11.24
HR (/min)	CPB	315 ± 30	286 ± 28	305 ± 42	310 ± 37
	Sham	325 ± 34	320 ± 25	315 ± 20	324 ± 15
pH	CPB	7.41 ± 0.03	7.34 ± 0.05ac	7.33 ± 0.06ac	7.39 ± 0.02
	Sham	7.40 ± 0.02	7.41 ± 0.03	7.39 ± 0.02	7.40 ± 0.02
PaO2 (mmHg)	CPB	399 ± 23	209 ± 94ac	125 ± 40ac	366 ± 40
	Sham	402 ± 22	396 ± 17	396 ± 14	402 ± 20
BE	CPB	-1.86 ± 0.35	-3.36 ± 1.22ac	-4.30 ± 1.84ac	-2.30 ± 1.50
	Sham	-1.96 ± 0.45	-2.36 ± 0.75	-1.54 ± 0.85	-1.95 ± 0.54
Hct (%)	CPB	41.80 ± 6.73	26.45 ± 4.24ac	21.54 ± 3.71ac	27.82 ± 3.66ac
	Sham	41.10 ± 1.85	40.20 ± 1.53	40.60 ± 1.46	39.80 ± 1.35
RT (°C)	CPB	36.17 ± 1.85	33.17 ± 1.83ab	35.12 ± 2.05	36.21 ± 1.24
	Sham	36.25 ± 1.42	37.35 ± 1.65	36.42 ± 1.05	36.85 ± 1.06

MAP: Blood pressure; Hct: Hematocrit; RT: Rectal temperature; BE: Buffer excess.

^aP < 0.05 vs baseline;

^cP < 0.05 vs Sham group.

Table 2 Levels of plasma DAO and d-lactate (n = 10, mean ± SD)

Variables	Groups	Pre-CPB	60 min after CPB	2 h after CPB
DAO (U/L)	CPB	0.543 ± 0.061	0.898 ± 0.062ac	1.038 ± 0.252ace
	Sham	0.562 ± 0.035	0.603 ± 0.045	0.625 ± 0.054
d-lactate (mg/L)	CPB	5.697 ± 0.272	8.688 ± 0.704ac	9.377±0.769ace
	Sham	5.745 ± 0.364	5.983 ± 0.632	6.136 ± 0.847

^aP < 0.05 vs baseline;

^cP < 0.05 vs Sham group;

^eP < 0.05 vs CPB 60 min.