Viral Hepatitis
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Oct 7, 2008; 14(37): 5674-5682
Published online Oct 7, 2008. doi: 10.3748/wjg.14.5674
Table 1 MHC-I binding predictions of 144-183 residue of HbcAg, processed by the SMM method
AllelePosition (aa)Pep lengthSequenceIC50 (nm)1
HLA A*3101148-15710VVRRRGRSPR30.9
HLA A*3101150-15910RRRGRSPRRR13.7
HLA A*3101157-16610RRRTPSPRRR19.2
HLA A*3101159-1679RTPSPRRRR38.4
HLA A*3101165-17410RRRSQSPRRR19.2
HLA A*3101166-17510RRSQSPRRRR35.4
HLA A*3101167-1759RSQSPRRRR13.7
HLA A*3201159-1679RTPSPRRRR48.6
HLA A*6801145-1549ETTVVRRRGR23
HLA A*6801146-1549TTVVRRRGR22.3
HLA B*0702162-1709SPRRRRSQS21.3
HLA B*0702170-1789SPRRRRSQS21.3
HLA B*0702155-1639SPRRRTPSP40.4
HLA B*0801162-1709SPRRRRSQS39.5
HLA B*0801170-1789SPRRRRSQS39.5
HLA B*2705150-15910RRRGRSPRRR49.5
HLA B*2705164-17310RRRRSQSPRR14.7
HLA B*2705166-17510RRSQSPRRRR33.9
Table 2 Deletion of aa 1-11 in preS1 in the different HBV genotypes
GenotypeGenBank No.Clinic statusCountries/districtRef.
Human
Genotype CAF223959CHBVietnamErik et al, 2001
AY217372CHBChinaLuo et al, 2004
AB195945CHBJapanHoriike et al, 2007
EF533714HCCChina1Gao et al, 2007
AY206389HCCChina1Lin et al, 2002
AB014395HCCJapanTakahashik et al, 1998
AY641563HCCSouth KoreaSong et al, 2005
D1666AHBJapanUchida et al, 1995
X98076FHBSwitzerlandPult et al, 1997
Genotype DAB033559CHBPapua New GuineaOkamoto et al, 1988
AB119256CHBJapanMichitaka et al, 2006
M32138Anti-HBeFranceTong et al, 1990
AY902777FHBMontanaGarfein et al, 2004
Genotype AAF297621FHBAfricaOwiredu et al, 2001
U87743AHBSouth AfricaBowyer et al, 1997
X69458AHBZimbabweChirara et al, 1994
Ape
GibbonAB037928East AsiaAiba et al, 2003
ChimpanzeeD00220HBsAg (+)LondonVaudin et al, 1988
GorilaAJ131567HBsAg (+)JapanGrethe et al, 2000
OrangutanAF193864CHBBorneanVerschoor et al, 2001
Recombination
Human-GibbonAB048705HBsAg (+)Australian AboriginesSugauchi et al, 2001