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Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Oct 7, 2008; 14(37): 5641-5649
Published online Oct 7, 2008. doi: 10.3748/wjg.14.5641
Table 1 Membrane transporters in hepatocytes
AbbreviationFunction
Basolateral membrane (sinusoidal)
NTCP/SLC10A11Takes up BAs
OATP/SLC21A1Takes up BAs and OA- and exports BAs, GSH, HCO3-
MRP3/ABCC3Export OA- conjugates, GSH
MRP4/ABCC4Export BAs, GSH
OSTa /OSTbOrganic solute transporter: Exports BAs
NBC4c/SLC4A51Na+-HCO3- symporter, acid extruder
NHE1/SLC9A11Na+/H+ exchanger, acid extruder
SK2Potassium channel, potassium efflux
SLC12A2Na+-K+-Cl- symporter: Sodium, potassium, chloride uptake
Apical membrane (canalicular)
BSEP/ABCB111, formerly SPGEBile salt export pump
MRP2/ABCC21, formerly cMOATExport non BAs OA-, GSH
MDR1Efflux of lipofilic cations
MDR3/ABCB4Phospholipid flipase
ABCG5/ABCG8Export sterols
AE2/SLC4A21Cl-/HCO3- anion exchanger: Acid loader
Cl- channel1Export chloride
AQP81Water channel
NHE3/SLC9A31Na+/H+ exchanger: Acid extruder
1Transporters relevant to bile flow under physiological basal conditions.
Table 2 Membrane transporters in cholangiocytes: Abbreviations and function
AbbreviationFunction
Basolateral membrane
NDCBE/SLC4A81Na+-dependent Cl-/HCO3- exchanger:
Import HCO3- and Na+, Export H+ and Cl-
NHE/SLC91Na+/H+ exchanger: Acid extruder
AQP41Water channel
tASBT/SLC10A2Export BAs and Na+
SK2Potassium channel, potassium efflux
SLC12A2Import Na+-K+-2Cl-
MRP3/ABCC3Export OA- conjugates, GSH
MRP4/ABCC4Export BAs, GSH
Apical membrane
AE2/SLC4A21Cl-/HCO3- anion exchanger: Acid loader
CFTR1Cl- channel: Export chloride
AQP11Water channel
NBCe/NBC4/SLC4A5Na+-HCO3- symporter: Acid extruder
ASBT/SLC10A2BAs-Na+, symport: Uptake of BAs and Na+
1Transporters relevant to bile flow under physiological basal conditions.