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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Sep 21, 2008; 14(35): 5448-5453
Published online Sep 21, 2008. doi: 10.3748/wjg.14.5448
Published online Sep 21, 2008. doi: 10.3748/wjg.14.5448
Table 1 Clinical, serological, virological and biochemical features of patients infected with HBV (mean ± SD)
| Clinica-status | Number (%) | Sex | Age (yr) | HBs Ag+ | Anti HBs+ | Anti HBc+ | Hbe Ag+ | Anti HBe+ | ALT (IU/L) | AST (IU/L) | Alk (U/L) | T-Bil (mg/dL) | Albumin (g/dL) | HBV DNA (log copies/mL) | |
| M | F | ||||||||||||||
| Inactive HBsAg carriers | 12 (19.4) | 9 | 3 | 30.6 ± | 12 | 0 | 12 | 3 | 9 | 38.3 ± | 31.4 ± | 282.2 ± | 0.7 ± | 4.77 ± | 4.3 ± |
| 9.5 | 25.8 | 12. | 199.9 | 0.241 | 1.25 | 1.57 | |||||||||
| Chronic hepatitis | 30 (48.4) | 25 | 5 | 34.5 ± | 30 | 0 | 30 | 81 | 221 | 250.9 ± | 104.4 ± | 243.6 ± | 1.17 ± | 4.2 ± | 5.31 ± |
| 11.6 | 120.7 | 74.7 | 125.4 | 0.49 | 0.7 | 1.48 | |||||||||
| Liver cirrhosis | 13 (21.0) | 9 | 4 | 44.5 ± | 13 | 0 | 13 | 5 | 8 | 50.3 ± | 64.6 ± | 274.2 ± | 1.41 ± | 3.6 ± | 5.8 ± |
| 9.4 | 18.8 | 32.2 | 229.3 | 0.63 | 0.67 | 2.03 | |||||||||
| HCC | 7 (11.3) | 6 | 1 | 47.7 ± | 7 | 0 | 7 | 0 | 7 | 123.5 ± | 285.1 ± | 402 ± | 2.92 ± | 3.1 ± | 7.22 ± |
| 13.7 | 64.1 | 196.8 | 114.3 | 1.5 | 0.48 | 2.01 | |||||||||
| Total | 62 (100) | 49 | 13 | 37.3 ± | 62 | 0 | 62 | 16 | 46 | 178.7 ± | 120.6 ± | 274.2 ± | 1.36 ± | 3.83 ± | 5.2 ± |
| (79.00%) | (21.00%) | 12.3 | 93.7 | 91.1 | 165.6 | 0.89 | 0.91 | 1.57 | |||||||
Table 2 Comparison of demographic and para-clinical features between HBeAg-positive and anti-HBe-positive individuals (mean ± SD)
| HBeAg-positive (n = 16) | Anti-HBe-positive (n = 46) | P | |
| Age (yr) | 35.06 ± 12.8 | 38 ± 12.2 | NS |
| Sex (M/F) | 8/8 | 41/5 | 0.002 |
| Genotype | D | D | NS |
| ALT (IU/L) | 70.7 ± 63.5 | 101.7 ± 204.3 | NS |
| AST (IU/L) | 69.3 ± 67.6 | 98.6 ± 134.07 | NS |
| T-Bil (mg/dL) | 1.18 ± 0.58 | 1.43 ± 0.97 | NS |
| HBV DNA (log copies/mL) | 6.21 ± 1.7 | 5.2 ± 1.57 | NS |
Table 3 The rate and percentage of BCP/C region mutations in HBV isolated among different clinical groups n (%)
| Mutation | Inactive HBsAg carriers (n = 12) | Chronic hepatitis (n = 30) | Liver cirrhosis(n = 13) | HCC (n = 7) | Total rate (%) |
| A1757 | 12 (100) | 25 (83.3) | 11 (84.61) | 5 (71.42) | 85.4 |
| C1753 | 1 (8.3) | 5 (16.6) | 5 (38.46) | 4 (57.14) | 24.2 |
| T1762/A1764 | 5 (41.6) | 11 (36.6) | 4 (30.76) | 3 (42.85) | 37.1 |
| A1899 | 3 (25) | 9 (30) | 8 (61.5) | 3 (42.85) | 37.1 |
| A1896 | 5 (41.6) | 19 (63.3) | 6 (46.15) | 6 (85.71) | 58.1 |
| T1766/A1768 | 1 (8.3) | 4 (13.3) | 2 (15.38) | 1 (14.28) | 12.9 |
| T1764/G1766 | 1 (8.3) | 5 (16.6) | 1 (7.69) | 2 (28.5) | 14.5 |
- Citation: Bahramali G, Sadeghizadeh M, Amini-Bavil-Olyaee S, Alavian SM, Behzad-Behbahani A, Adeli A, Aghasadeghi MR, Amini S, Mahboudi F. Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients. World J Gastroenterol 2008; 14(35): 5448-5453
- URL: https://www.wjgnet.com/1007-9327/full/v14/i35/5448.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.5448