Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver

Table 1 Clinical parameters, oxidative and antioxidative parameters in sham, I/R and I/R + NS rats (n = 10, mean  ±  SD)

	Sham	I/R	I/R + NS	P
Clinical parameters
AST (U/L)	132 ± 22	952 ± 251b	571 ± 137df	0.001
ALT (U/L)	86 ± 17	695 ± 206b	321 ± 128df	0.001
LDH (U/L)	534 ± 181	4334 ± 760b	3113 ± 729de	0.001
TAC (nmol Trolox Eqv./mg protein)	2.96 ± 0.4	2.17 ± 0.6a	3.07 ± 0.2e1	0.029
TOS (nmol H2O2 Eqv./mg protein)	10.4 ± 2.2	15.9 ± 2.0b	12.8 ± 3.112	0.003
OSI (Arbitrary Unite)	3.54 ± 0.7	7.76 ± 1.9b	3.76 ± 0.612	0.002
MPO (U/g protein)	9.4 ± 1.8	13.2 ± 1.7b	11.2 ± 2.2f1	0.004
CAT (U/mg protein)	18.4 ± 3.9	10.1 ± 1.9b	18.3 ± 2.212	0.004

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase; TAC: Total antioxidant capacity; TOS: Total oxidative status; OSI: Oxidative stress index; MPO: Myeloperoxidase; CAT: Catalase.

^aP < 0.05,

^bP < 0.01, Sham groups vs I/R groups;

^dP < 0.01, Sham groups vs I/R + NS groups;

^eP < 0.05,

^fP < 0.01, I/R groups vs I/R + NS groups.

¹P > 0.05, Sham groups vs I/R + NS groups;

²P < 0.001, I/R groups vs I/R + NS groups.