Colorectal Cancer
Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Sep 7, 2008; 14(33): 5162-5175
Published online Sep 7, 2008. doi: 10.3748/wjg.14.5162
Table 1 IC50 and sensitization ratio of taxol and its combinations with Rosco towards human colorectal cancer cell lines
Treatment with taxol and combinations with RoscoIC50 (mol/L)
Sensitization ratio1
SW48SW1116SW837SW48SW1116SW837
Taxol4.8 × 10-81.2 × 10-73.8 × 10-7---
Taxol + 5 μg/mL Rosco7.4 × 10-101.0 × 10-85.4 × 10-865127
Taxol + 10 μg/mL Rosco7.5 × 10-118.1 × 10-106.7 × 10-106.4 × 1021.5 × 1025.7 × 102
1Sensitization ratio = IC50 (taxol)/IC50 (taxol + Rosco).
Table 2 Analysis of the combined effects of taxol and Rosco on human colorectal cancer cell lines
Combined treatment of taxol and RoscoCombination interaction at various durations of treatment in human colorectal cancer cells1
SW48SW1116SW837
2 d4 d6 d2 d4 d6 d2 d4 d6 d
Taxol 0.5 IC50 + Rosco 1.0 μg/mLantantantantantsynantantsyn
Taxol 1.0 IC50 + Rosco 10 μg/mLantantaddantantantantantsyn
Taxol 2.0 IC50 + Rosco 15 μg/mLantantantsynantantantantant
Taxol 3.0 IC50 + Rosco 20 μg/mLantantantantantantantantant
Taxol 4.0 IC50 + Rosco 25 μg/mLantaddaddsynantaddantantant
1The data are based on the mean of absorbance measurements of 3 independent experiments. ant: Antagonistic; add: Additive; syn: Synergistic.
Table 3 IC50 and sensitization ratio of 5-FU and its combinations with Rosco towards human colorectal cancer cell lines
Treatment with 5-FU and combinations with RoscoIC50 (mol/L)
Sensitization ratio1
SW48SW1116SW837SW48SW1116SW837
5-FU4.8 × 10-52.5 × 10-54.8 × 10-5---
5-FU + 5 μg/mL Rosco5.7 × 10-96.7 × 10-61.8 × 10-68.42 × 1033.7326.7
5-FU + 10 μg/mL Rosco5.7 × 10-91.0 × 10-79.1 × 10-98.42 × 1032505.28 × 103
1Sensitization ratio = IC50 (5-FU)/IC50 (5-FU + Rosco).
Table 4 Analysis of the combined effects of 5-FU and Rosco on human colorectal cancer cell lines
Combined treatment of 5-FU and RoscoCombination interaction at various durations of treatment in human colorectal cancer cells1
SW48SW1116SW837
2 d4 d6 d2 d4 d6 d2 d4 d6 d
5-FU 0.5 IC50 + Rosco 1.0 μg/mLantantantsynsynsynantantadd
5-FU 1.0 IC50 + Rosco 15 μg/mLantantantsynsynsynantsynadd
5-FU 2.0 IC50 + Rosco 20 μg/mLantantantsynaddaddaddantant
5-FU 3.0 IC50 + Rosco 25 μg/mLantantaddantantantaddantant
1The data are based on the mean of absorbance measurements of 3 independent experiments; ant: Antagonistic; add: Additive; syn: Synergistic.
Table 5 IC50 and sensitization ratio of doxorubicin and combinations with Rosco towards human colorectal cancer cell lines
Treatment with doxorubicin and its combinations with RoscoIC50 (mol/L)
Sensitization ratio1
SW48SW1116SW837SW48SW1116SW837
Dox.5.4 × 10-86 × 10-74.1 × 10-7---
Dox. + 5 μg/mL Rosco5.8 × 10-112 × 10-74.1 × 10-89.3 × 102310
Dox. + 10 μg/mL Rosco5.8 × 10-114.5 × 10-98.2 × 10-109.3 × 1021.3 × 1025.0 × 102
1Sensitization ratio = IC50 (Dox.)/IC50 (Dox. + Rosco).
Table 6 Analysis of the combined effects of doxorubicin and Rosco on human colorectal cancer cell lines
Combined treatment of doxorubicin and RoscoCombination interaction at various durations of treatment in human colorectal cancer cells1
SW48SW1116SW837
2 d4 d6 d2 d4 d6 d2 d4 d6 d
Dox 0.5 IC50 + Rosco 1.0 μg/mLantantantsynsynsynsynsynsyn
Dox 1.0 IC50 + Rosco 10 μg/mLantantantsynsynsynsynsynsyn
Dox 2.0 IC50 + Rosco 15 μg/mLantantantsynsynsynsynsynsyn
Dox 3.0 IC50 + Rosco 20 μg/mLantaddaddsynsynaddsynsynadd
Dox 4.0 IC50 + Rosco 25 μg/mLantaddaddsynantaddsynantant
1The data are based on the mean of absorbance measurements of 3 independent experiments; ant: Antagonistic; add: Additive; syn: Synergistic.
Table 7 IC50 and sensitization ratio of vinblastine and its combinations with Rosco towards human colorectal cancer cell lines
Treatment with vinblastine and combinations with RoscoIC50 (mol/L)
Sensitization ratio1
SW48SW1116SW837SW48SW1116SW837
Vinb.1 × 10-86.3 × 10-74.2 × 10-7---
Vinb. + 5 μg/mL Rosco5.4 × 10-117.5 × 10-85.0 × 10-81.9 × 1028.48.4
Vinb. + 10 μg/mL Rosco5.4 × 10-117.9 × 10-104.6 × 10-101.9 × 1028.0 × 1029.1 × 102
1Sensitization ratio = IC50 (Vinb.)/IC50 (Vinb. + Rosco).
Table 8 Analysis of the combined effects of vinblastine and Rosco on human colorectal cancer cell lines
Combined treatment of vinblastine and RoscoCombination interaction at various durations of treatment in human colorectal cancer cells1
SW48SW1116SW837
2 d4 d6 d2 d4 d6 d2 d4 d6 d
Vinb 1.0 IC50 + Rosco 10 μg/mLantantantaddaddaddantsynsyn
Vinb 2.0 IC50 + Rosco 15 μg/mLantsynantsynantantantantant
Vinb 3.0 IC50 + Rosco 20 μg/mLantantantsynantantantantant
Vinb 4.0 IC50 + Rosco 25 μg/mLantantantsynantantantantant
1The data are based on the mean of absorbance measurements of 3 independent experiments; ant: Antagonistic; add: Additive; syn: Synergistic.