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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jul 28, 2008; 14(28): 4462-4472
Published online Jul 28, 2008. doi: 10.3748/wjg.14.4462
Published online Jul 28, 2008. doi: 10.3748/wjg.14.4462
Table 1 Fat pad weights (g)
Table 2 Incidences of the observed histopathological lesions in liver samples
Lean | Obese | ER | ||
Control | Whey + Ca | |||
Number of samples | 8 | 10 | 10 | 10 |
No abnormalities detected | 8 | 0 | 0 | 0 |
Macrovesicular fatty change (total) | 0 | 10 | 10 | 10 |
Severe | 0 | 1 | 0 | 0 |
Marked | 0 | 1 | 0 | 0 |
Moderate | 0 | 5 | 5 | 4 |
Slight | 0 | 3 | 5 | 5 |
Minimal | 0 | 0 | 0 | 1 |
Infiltration of inflammatory cells, minimal | 0 | 1 | 1 | 3 |
Focal hepatocyte necrosis, total | 0 | 2 | 0 | 2 |
Slight | 0 | 1 | 0 | 0 |
Minimal | 0 | 1 | 0 | 2 |
Table 3 Concentrations of primary metabolites in liver samples (&mgr;mol/g tissue)
Lean | Obese | ER | ANOVA P value | ||
Control | Whey + Ca | ||||
Glucose-6-phosphate | 28.6 ± 2.7a | 19.2 ± 3.5 | 22.7 ± 1.7h | 11.2 ± 3.2f | < 0.0001 |
Fructose-6-phosphate | 7.0 ± 0.7 | 4.9 ± 0.6 | 6.9 ± 0.7h | 3.2 ± 0.9e | 0.001 |
Mannose-6-phosphate | 1.7 ± 0.2 | 1.7 ± 0.2 | 1.4 ± 0.1g | 0.8 ± 0.2cf | 0.0003 |
Fructose bisphosphate | 3.2 ± 0.6 | 8.7 ± 2.0 | 9.5 ± 2.4dh | 0.5 ± 0.1b | 0.0005 |
Glycerate-3-phosphate | 26.2 ± 3.7 | 21.0 ± 0.8 | 17.4 ± 1.2d | 13.1 ± 1.4f | 0.0008 |
Ribose-5-phosphate | 0.3 ± 0.02a | 0.7 ± 0.1 | 0.7 ± 0.1di | 1.3 ± 0.1cf | < 0.0001 |
Succinate | 24.5 ± 3.3c | 5.3 ± 1.1 | 6.7 ± 2.4fi | 24.0 ± 4.0c | < 0.0001 |
Malate | 42.0 ± 5.2a | 54.5 ± 3.7 | 61.3 ± 4.7dg | 40.5 ± 5.1a | 0.008 |
Citrate | 4.9 ± 0.7c | 2.0 ± 0.3 | 1.6 ± 0.2f | 1.8 ± 0.3f | < 0.0001 |
Pyruvate | 5.6 ± 0.8c | 0.9 ± 0.2 | 2.6 ± 0.4e | 1.5 ± 0.3f | < 0.0001 |
Phosphoenolpyruvate | 2.8 ± 0.8 | 2.3 ± 0.3 | 1.4 ± 0.2 | 1.2 ± 0.2 | 0.0426 |
6-phosphogluconate | 3.5 ± 0.2a | 2.4 ± 0.2 | 3.7 ± 0.2eg | 2.6 ± 0.4a | 0.0023 |
Fumarate | 9.6 ± 1.0a | 10.4 ± 1.1 | 17.8 ± 1.7bfg | 11.9 ± 1.3a | 0.0003 |
- Citation: Pilvi TK, Seppänen-Laakso T, Simolin H, Finckenberg P, Huotari A, Herzig KH, Korpela R, Orešič M, Mervaala EM. Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction. World J Gastroenterol 2008; 14(28): 4462-4472
- URL: https://www.wjgnet.com/1007-9327/full/v14/i28/4462.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.4462