Prognostic impact of metastatic lymph node ratio in advanced gastric cancer from cardia and fundus

Table 1 Univariate survival analysis of MLR and clinicopathological characteristics in 236 patients undergoing curative surgery

Characteristics	n	Median survival time (mo)	5-yr survival (%)	χ2	P
Gender				4.26	0.0389
Male	197	45	36.3
Female	39	51	43.6
Age (yr)				1.18	0.2777
< 60	103	45	39.0
≥ 60	133	46	36.6
Tumor size (cm)				18.48	0.0000
< 3	88	60	45.5
3-6	97	47	39.7
> 6	51	32	18.1
Borrmann’s type1				7.41	0.0065
BorrmannI, II	172	50	41.7
Borrmann III, IV	64	41	26.5
Histological type				5.07	0.0243
Differentiated	213	47	38.9
Undifferentiated	23	35	19.9
pT category				49.42	0.0000
pT2	25	72	84.0
pT3	118	54	40.2
pT4	93	29	20.8
pN category				87.7	0.0000
pN0	42	65	73.2
pN1	97	55	42.4
pN2	68	27	19.9
pN3	29	17	0.0
Num of dissected LNs				8.22	0.0042
< 15	36	27	22.4
≥ 15	200	49	39.1
MLR				34.3	0.0000
< 10%	59	63	60.5
~ 20%	58	46	34.1
~ 30%	33	44	33.5
> 30%	86	28	21.0
Type of gastrectomy				2.98	0.0844
TG	190	46	39.3
PSG	46	45	31.3

¹Borrmann’s type: Macroscopic appearances of primary tumor, classified as TypeI: polypoid tumors; Type II: ulcerated carcinomas with demarcated and raised margins; Type III: ulcerated carcinomas without definite limits, infiltrating into the surrounding wall; Type IV: diffusely infiltrating carcinomas.

Table 2 Multiple stepwise regression analysis with Cox proportional hazards model

Characteristics	β	Wald	P	RR	95% CI for RR
					Low	High
MLR excluded
Tumor size		6.665	0.039
3-6 cm vs < 3 cm	0.222	1.938	0.164	1.249	0.913	1.707
> 6 cm vs < 3 cm	0.501	6.636	0.010	1.650	1.127	2.414
pT category		27.747	0.002
pT3 vs pT2	0.761	9.184	0.000	2.140	1.308	3.499
pT4 vs pT2	1.286	24.369	0.000	3.617	2.171	6.026
pN category		65.066	0.000
pN1 vs pN0	0.618	9.792	0.002	1.855	1.260	2.733
pN2 vs pN0	1.224	30.727	0.000	3.402	2.206	5.244
pN3 vs pN0	2.156	57.470	0.000	8.639	4.947	15.090
Num of total LNs	-0.682	10.684	0.001	0.506	0.336	0.761
MLR included
Tumor size		7.985	0.018
3-6 cm vs < 3 cm	0.307	3.863	0.049	1.359	1.001	1.845
> 6 cm vs < 3 cm	0.512	7.353	0.007	1.668	1.152	2.415
pT category		30.821	0.000
pT3 vs pT2	0.772	9.940	0.002	2.165	1.339	3.500
pT4 vs pT2	1.343	26.759	0.000	3.832	2.303	6.37
MLR	2.569	69.390	0.000	13.06	7.134	23.900

Table 3 Estimation based on multiple linear regression model (stepwise method)

Parameters	β	t	P	95% CI forβ
Tumor size	-0.11	-1.97	0.051
MLR	-0.63	-10.4	0.000	-0.71 to -0.51
Intercept (constant)	0.56	19.0	0.000	0.48 to 0.59