Epstein-Barr virus is associated with gastric carcinoma: The question is what is the significance?

Table 1 Distribution of Epstein-Barr virus-association with gastric adenocarcinoma

	Gastric adenocarcinoma					Gastric adenocarcinoma intestinal type					Gastric adenocarcinoma diffuse type
	n	Total	EBV +	Crude frequency (%)	Adjusted frequency (%)	n	Total	EBV +	Crude frequency (%)	Adjusted frequency (%)	n	Total	EBV +	Crude frequency (%)	Adjusted frequency (%)
EUROPE	18	2296	201	8.75	7.96	4	338	27	7.99	2.94	4	173	9	5.2	7.83
East Europe	4	293	43	14.7	26.3	1	13	0	0	---	1	19	4	21.1	---
Poland	3	87	25	28.7	40	1	13	0	0	---	1	19	4	21.1	---
Russia	1	206	18	8.74	---	---	---	---	---	---	---	---	---	---	---
Central Europe	13	1938	154	7.95	7.58	3	325	27	8.31	2.94	3	154	5	3.25	4.55
United Kingdom	4	682	12	1.76	1.7	---	---	---	---	---	---	---	---	---	---
France	1	59	5	8.47	---	1	21	0	0	---	1	22	1	4.55	---
Germany	1	35	3	8.57	---	1	17	1	5.88	---	1	18	2	11.1	---
Netherlands	7	1162	134	11.5	7.58	1	287	16	9.06	---	1	114	2	1.75	---
South Europe	1	65	4	6.15	---	---	---	---	---	---		---	---	---	---
Italy
ASIA	77	29076	2324	7.99	9.65	21	6367	430	6.75	5.82	21	4862	441	9.07	11.2
South-East Asia	72	28760	2253	7.83	9.56	19	6290	414	6.58	5.82	18	4665	398	8.53	6.89
Taiwan	3	486	77	15.8	20	2	129	23	17.8	19	2	103	24	23.3	21.2
Papua New Guinea	1	150	2	1.33	---	1	72	0	0	---	1	78	2	1.33	---
Korea	13	4784	300	6.27	5.7	2	233	4	1.72	1.71	2	319	22	6.9	6.89
Japan	45	21956	1750	7.97	11.6	11	5480	353	6.44	5.82	11	4011	346	8.63	11.2
China	10	1384	124	8.96	7.74	3	376	34	9.04	10.7	2	154	4	3.25	1.43
South Asia	2	112	21	18.8	17.6	---	---	---	---	---	1	70	8	11.4	---
India	1	60	20	33.3	---						1	70	8	11.4	---
Pakistan	1	52	1	1.92	---						---	---	---	---	---
Central-western Asia	3	204	51	25	10.8	2	77	16	20.8	26.9	2	127	35	27.6	37.7
Kazakhstan	2	139	14	10.1	9.89	1	48	1	2.08	---	1	91	13	14.3	---
Turkey	1	65	37	56.9	---	1	29	15	51.7	---	1	36	22	61.1	---
AMERICA	19	2099	249	11.9	11.3	14	2082	95	4.56	8.3	13	811	124	15.3	13.3
South America	8	927	124	13.4	12.2	7	503	47	9.34	8.77	6	381	75	19.7	18.8
Colombia	2	294	31	10.5	9.92	1	91	11	10.5	---	1	86	12	14	---
Chile	1	278	53	20.2	---	2	178	23	12.9	14.5	3	193	52	26.9	29.6
Brazil	4	355	40	11.3	11.3	4	234	13	5.56	4.35	2	102	11	10.8	6.55
Central America	4	630	55	8.73	9.86	3	241	8	3.32	2.84	3	319	38	11.9	12.8
Mexico
North America	7	542	70	12.9	10.2	4	338	40	11.8	10.8	4	111	11	9.91	8.63
United States
GLOBAL ANALYSIS	114	33471	2775	8.29	9.67	39	7786	552	7.08	5.88	38	5846	574	9.82	12.1

Distribution of EBV association with Gastric Adenocarcinoma.