Role of cytokines in inflammatory bowel disease

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Jul 21, 2008 (publication date) through Dec 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2008; 14(27): 4280-4288
Published online Jul 21, 2008. doi: 10.3748/wjg.14.4280

Table 1 Role of cytokines and cell lines involved in their production in patients with IBD

Cytokine	UC	CD	Cells involved in the production
TNF-α	Up-regulated	Up-regulated	Macrophages
TL1α	Unknown	Up-regulated	Th1
IL-1β	IL-1ra/IL-1 ratio	IL-1ra/IL-1 ratio	Macrophages
IL-6	Up-regulated	Up-regulated	Macrophages, DC, Th17 and others
IL-18	Not	Yes, not in all patients	Macrophages
TGF-β	Not clear, maybe defective signalling	Not clear, maybe defective signalling	Th0, Th3, Treg
IL-10	Not clear	Yes, up-regulated	Tr1 and Breg
IL-4	Not clear	Not clear	Th2, NK
IL-12	Up-regulated	Up-regulated	Macrophages, DC
IL-23	Yes	Yes	Macrophages, DC
IL-27	Not clear	Up-regulated	APCs
IL-17	Up-regulated	Up-regulated	Th17
IL-13	Up-regulated	Not	Th1, NK
IL-5	Up-regulated	Not	Th2, NK

Citation: Sanchez-Muñoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. Role of cytokines in inflammatory bowel disease. World J Gastroenterol 2008; 14(27): 4280-4288
URL: https://www.wjgnet.com/1007-9327/full/v14/i27/4280.htm
DOI: https://dx.doi.org/10.3748/wjg.14.4280