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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jul 7, 2008; 14(25): 4028-4039
Published online Jul 7, 2008. doi: 10.3748/wjg.14.4028
Published online Jul 7, 2008. doi: 10.3748/wjg.14.4028
Table 1 Criteria for macroscopic grading of the experimental colitis
Macroscopic grading | ||||
Feature | 0 | 1 | 2 | 3 |
Stool | Normal | Loose stool | Diarrhea | Diarrhea with blood |
Hyperemia | None | Focal | Focal and thickening of bowel wall | Extensive thickening of bowel wall |
Adhesions | None | Mild | Moderate | Extensive |
Megacolon | None | Mild | Moderate | Toxic megacolon |
Ulcerations | None | Mild ulceration on one side < 1 cm | Moderate ulceration > 1 cm | Severe damage extending > 2 cm |
Table 2 Criteria for microscopic grading of experimental chronic colitis
Histologic grading | ||||
Feature | 0 | 1 | 2 | 3 |
Abnormalities of mucosal architecture | None (Normal) | Mild or focal, not exceeding lamina propria | Moderate, not exceeding the submucosa | Severe & diffuse, exceeding the submucosa |
Crypt abnormalities | None | Mild atrophy | Moderate atrophy, Branched crypts | Severe atrophy, branched crypts, cryptitis, crypt abscess |
Inflammatory cell infiltration | Normal | Scattered cells | Moderate or confluent cells | Massive infiltration of cells |
Vascular dilatation | Normal blood vessels | Mild dilatation (localized) | Moderate dilatation of several blood vessels | Severe generalized dilatation of blood vessels |
Edema | None | Low level limited to villi | In the submucosa | All over the section |
Mast cells | Normal scattered cells | Three cells clustered in submucosa | Clusters of > 3 cells in the submucosa | Clusters in submucosa and serosa |
- Citation: Hussein IAH, Tohme R, Barada K, Mostafa MH, Freund JN, Jurjus RA, Karam W, Jurjus A. Inflammatory bowel disease in rats: Bacterial and chemical interaction. World J Gastroenterol 2008; 14(25): 4028-4039
- URL: https://www.wjgnet.com/1007-9327/full/v14/i25/4028.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.4028