Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters

Table 1 Relationship between expressions of E-cadherin/P120 catenin and histological features of ICC n (%)

	E-cadherin				P120 catenin
	n	+	-	P value	+	-	P value
Differentiation grade
Well	3	3 (100)	0 (0)	0.009	3 (100)	0 (0)	0.003
Mediate	14	7 (50.0)	7 (50.0)		5 (35.7)	9 (64.3)
Poor	25	5 (20.0)	20 (80.0)		3 (12.0)	22 (88.0)
pTNM
I	2	2 (100)	0 (0)	0.035	2 (100)	0 (0)	0.004
II	9	5 (55.6)	4 (44.4)		5 (55.6)	4 (44.4)
III	25	8 (32.0)	17 (68.0)		4 (16.0)	21 (84.0)
IV	6	0 (0)	6 (100)		0 (0)	6 (100)

Table 2 Relationship between expressions of E-cadherin/P120 catenin and clinical parameters of ICC n (%)

	E-cadherin				P120 catenin
	n	+	-	P value	+	-	P value
Size
< 5 cm	17	7 (41.2)	10 (58.8)	0.826	6 (35.3)	11 (64.7)	0.584
5-10 cm	16	5 (31.3)	11 (68.7)		3 (18.8)	12 (81.2)
> 10 cm	9	3 (33.3)	6 (66.7)		2 (22.2)	7 (77.8)
Capsular invasion
+	6	4 (66.7)	2 (33.3)	0.164	3 (50)	3 (50)	0.391
-	36	11 (30.6)	25 (69.4)		8 (22.2)	28 (77.8)
Satellite nodules
+	11	4 (36.4)	7 (65.6)	1	3 (27.3)	8 (72.7)	0.314
-	31	11 (35.5)	20 (64.5)		8 (25.8)	23 (74.2)
Vascular invasion
+	13	2 (15.4)	11 (84.6)	0.089	1 (7.7)	12 (92.3)	0.127
-	29	13 (44.8)	16 (55.2)		10 (34.5)	19 (65.5)
L.N.P
+	7	1 (14.3)	6 (85.7)	0.39	0 (0)	7 (100)	0.161
-	35	14 (40)	21 (60)		11 (31.4)	24 (68.6)
I.M.
+	10	0 (0)	10 (100)	0.007	0 (0)	10 (100)	0.041
-	32	15 (46.9)	17 (53.1)		11 (34.4)	21 (65.6)

Table 3 Relationship between expression of E-cadherin and P120 catenin in ICC

	P120
E-cadherin	+	-	P value
+	9	6	0.000
-	2	25

Table 4 Cox multivariate analysis for survival of 37 patients

	Sig	RR	95% CI
			Lower	Upper
E-cadherin expression	0.724	1.525	0.147	15.827
P120 expression	0.049	0.088	0.008	0.991
Differentiation	0.194	0.407	0.105	1.583
pTNM stage	0.073	2.898	0.904	9.288
Tumor size	0.037	0.387	0.159	0.944
Capsular invasion	0.052	17.046	0.981	6.166
Satellite nodules	0.709	1.597	0.137	18.578
Vascular invasion	0.948	0.961	0.284	3.247
Limph node invasion	0.087	4.72	0.8	27.855
Intrahepatic metastasis	0.786	1.352	0.154	11.899

Sig: Significance; RR: Relative risk; CI: Confidence interval.