Preventive effect of Qianggan-Rongxian Decoction on rat liver fibrosis

Table 1 Serum levels of HA, LN, and type IV collagen (mean ± SD)

Groups	n	HA (ng/mL)	LN (ng/mL)	Type IV collagen (ng/mL)
Control	12	19.81 ± 2.86	11.02 ± 1.70	13.49 ± 2.49
Model	10	44.64 ± 3.09c	33.27 ± 5.81c	62.71 ± 19.16c
High-dose DMN group	10	23.14 ± 4.58ac	14.02 ± 2.63ac	22.10 ± 2.44ac
Medium-dose DMN group	12	22.58 ± 3.60a	13.87 ± 1.45a	25.64 ± 4.68ac
Low-dose DMN group	10	26.08 ± 5.62ac	19.12 ± 5.02ac	27.64 ± 4.68ac

^aP < 0.05 vs model group;

^cP< 0.05 vs control group.

Table 2 Area occupied by the fibrotic septa and its ratio to the total area examined (mean ± SD)

Groups	n	Area covered by fibrotic septa (&mgr;m2)	Ratio (%)
Control	12	10.33 ± 6.89	0.12 ± 0.08
Model	10	221.23 ± 51.21c	2.00 ± 0.20c
High-dose DMN group	10	59.32 ± 10.41ac	1.60 ± 0.24ac
Medium-dose DMN group	12	21.73 ± 15.42ac	1.06 ± 0.13ac
Low-dose DMN group	10	61.73 ± 15.42ac	1.68 ± 0.14ac

^aP < 0.05 vs model group;

^cP < 0.05 vs control group.

Table 3 Serum levels of ALT and AST (mean ± SD)

Groups	n	Area covered by fibrotic septa (&mgr;m2)	Ratio (%)
Control	12	63.0 ± 11.9	307 ± 23
Model	10	1931 ± 552c	2696 ± 764c
High-dose DMN group	10	960 ± 557ac	1560 ± 965ac
Medium-dose DMN group	12	739 ± 345ac	1239 ± 725ac
Low-dose DMN group	10	983 ± 460ac	1631 ± 859ac

^aP < 0.05 vs model group;

^cP < 0.05 vs control group.