Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea

Table 1 Baseline characteristics of 48 patients with HCC

Characteristics
Mean age (yr)	50 (20-71)
Sex (M:F)	35:13
Etiology of liver disease
HBV	38
HCV	3
Non-HBV, Non-HCV	7
Tumor size
≤ 3 cm	11
3-5 cm	15
> 5 cm	22
Mean ( range) (cm)	5.8 ± 3.9
UICC TNM stage
I	5
II	41
III	2
Edmonson-Steiner’s grade
I	8
II	13
III	20
IV	5
Underlying liver disease
Cirrhosis	22
Chronic hepatitis	26
AFP (ng/mL)
< 11	12
11-400	16
≥ 400	20

AFP: Alpha-fetoprotein.

Table 2 p53 mutation analysis in 48 patients with HCC

Mutation sites	n	Mutation sites	n
Exon 5		Exon 8
Arg(CGC)158Leu(CTC)	1	Arg(CGT)273Cys(TGT)	1
Exon 6		Exon 7
His(CAT)193Tyr(TAT)	1	Arg(TAC)236Cys(TGC)	1
Ser(AGT)215Arg(AGG)	1	Arg(TAC)236Asp(GAC)	1
Tyr(TAT)220Cys(TGT)	1	Met(ATG)246Leu(TTG)	1
		Met(ATG)246Val(GTG)	1