Reactive oxygen species and chemokines: Are they elevated in the esophageal mucosa of children with gastroesophageal reflux disease?

Table 1 The comparison of luminol, lucigenin, MCP-1 and IL-8 levels between endoscopic esophagitis and normal groups (mean ± SD)

	Esophagitis	Normal	P value1
Luminol (rlu/mg)	175.2 ± 98.5	152.7 ± 71.3	0.349
Lucigenin (rlu/mg)	154.1 ± 74.9	155.7 ± 79.9	0.939
MCP-1 (pg/mg)	39.8 ± 1.7	47.8 ± 1.7	0.248
IL-8 (pg/mg)	331.1 ± 2.9	323.6 ± 2.3	0.898

¹Student-t test.

Table 2 The comparison of luminol and lucigenin levels according to the severity of histopathological esophagitis (mean ± SD)

Vandenplas classification	Normal (n = 12)	Mild esophagitis (n = 43)	Moderate esophagitis (n = 4)	P value1
Luminol (rlu/mg)	129.9 ± 80.9	164.4 ± 76.3	236.8 ± 142.8	0.049
Lucigenin (rlu/mg)	156.8 ± 91.7	145.4 ± 65.4	244.8 ± 94.6	0.044

¹Kruskal Wallis test (normal vs moderate esophagitis).

Table 3 The comparison of MCP-1 and IL-8 levels according to the severity of histopathological esophagitis (mean ± SD)

Vandenplas classification	Normal (n = 12)	Mild esophagitis (n = 43)	Moderate esophagitis (n = 4)	P value1
MCP-1 (pg/mg)	38.9 ± 1.7	44.5 ± 1.7	53.7 ± 2.7	0.804
IL-8 (pg/mg)	262.4 ± 2.3	337.3 ± 2.5	630.9 ± 5.6	0.614

¹Kruskal Wallis test.