Systemic gemcitabine combined with intra-arterial low-dose cisplatin and 5-fluorouracil for advanced hepatocellular carcinoma: Seven cases

Table 1 Baseline profiles, response, and outcome of seven patients with HCC

Case	Age(yr)	Sex	PS	Hepatitis	Child-Pugh class	AFP (ng/mL)	L3 (%)	DCP (mAU/mL)	Main tumor size (mm)	Main tumor morphology	Vascular invasion	Tumor location	Tumor volume	Previous treatment	Treatment cycles	Response	Outcome (mo)	Cause of death
1	40	M	0	HBV	A	934.3	15.9	333	50	Massive	Vp3/Vv0	Bilobular, multiple	< 50%	None	2	PR	55, alive
2	35	M	0	HBV	A	593 350	1.9	> 2000	130	Massive	Vp4/Vv3	Bilobular, multiple	≥ 50%	HAI	3	PR	10, dead	Respiratory failure due to lung metastases
3	51	M	0	HBV	A	33 460	78	> 2000	80	Massive	Vp3/Vv0	Bilobular, multiple	< 50%	HAI	3	PR	8, dead	SAH due to a cerebral aneurysm
4	60	M	0	HCV	A	12.4	35.5	> 2000	45	Massive	Vp3/Vv0	Bilobular, multiple	≥ 50%	HAI	1	PR	6, dead	Intrahepatic HCC related liver failure
5	68	M	0	HCV	A	7.5	< 0.5	86	42	Nodular	Vp0/Vv0	Bilobular, multiple	< 50%	TACE	1	SD	25, dead	Aspiration-related pneumonia due to vertebra metastasis
6	64	M	0	HCV	A	127 920	64.3	698	45	Nodular	Vp3/Vv0	Bilobular, multiple	< 50%	TACE	2	SD	7, dead	Intrahepatic HCC related liver failure
7	42	M	0	HBV	A	372.8	67.5	15	100	Diffuse	Vp4/Vv0	Bilobular, multiple	≥ 50%	TACE	2	SD	5, dead	Intrahepatic HCC related liver failure

Vp0: No PVTT; Vp3: PVTT in the first branch; Vp4: PVTT in the trunk; Vv0: No hepatic venous tumor thrombus; Vv3: Hepatic venous tumor thrombus in inferior vena cava; Multiple lesions; massive type HCC; Nodular, nodular type HCC; diffuse type HCC; Bilobular: Lesions; HAI: Hepatic arterial infusion chemotherapy of low-dose cisplatin and 5-FU.

Table 2 NCI-CTC grade of adverse reactions during and after GEMFP

Case	Leukocyte count (pre/end, /&mgr;L)	Neutrophil count (pre/end, /&mgr;L)	Hemoglobin (pre/end, g/dL)	Platelet count (pre/end, × 104)	Nausea	Anorexia
1	3 (5050/1670)	3 (3232/835)	0 (14.6/11.8)	4 (7.5/1.5)	0	1
2	4 (7260/640)	4 (5520/420)	4 (15.7/6.2)	4 (14.8/1.8)	0	0
3	3 (3950/1720)	3 (2489/774)	0 (14.0/12.0)	4 (6.9/1.7)	0	0
4	3 (7950/1430)	4 (5168/352)	0 (16.1/11.7)	4 (20.7/2.0)	0	0
5	3 (3990/1700)	3 (2993/840)	0 (14.6/11.3)	3 (9.6/4.0)	1	0
6	3 (3840/1040)	4 (2380/357)	2 (15.2/8.5)	4 (15.3/0.5)	0	1
7	3 (6790/1950)	4 (3870/468)	2 (12.4/9.6)	2 (13.9/6.4)	0	0