Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines

Table 1 Effect of TSA on the survival of biliary tract cancer cell lines

Concentration of TSA	Percentage of survival of cell lines (median and quartile)
	QBC939	KMBC	OZ	Mz-ChA-l
0.10 &mgr;mol/L	92.87 (93.09)	93.27 (94.87)	83.07 (87.72)	83.26 (88.75)
0.25 &mgr;mol/L	33.38 (60.61)	34.88 (59.60)	36.63 (65.60)	38.58 (66.51)
0.50 &mgr;mol/L	24.90 (36.45)	24.86 (46.64)	26.90 (50.64)	27.90 (52.64)
1.00 &mgr;mol/L	16.99 (26.30)	17.09 (35.80)	18.46 (37.23)	18.46 (37.23)
1.50 &mgr;mol/L	11.29 (21.63)	11.32 (25.36)	12.29 (27.36)	12.79 (29.86)
2.00 &mgr;mol/L	6.52 (17.35)	6.28 (16.36)	6.28 (19.25)	9.03 (20.25)
Value of H	15.66	16.11	14.23	14.32
P	0.0082	0.0076	0.046	0.043

The survival percentage of cell lines treated with various doses of TSA was detected after 4, 12, 24, 36 and 48 h, respectively, by MTT assay. The MTT value was expressed as median and quartile.