Intraperitoneal administration of gonadotropin-releasing hormone-PE40 induces castration in male rats

Table 1 Anti-GnRH antibody titer, testosterol level and testis weight in rats of the control and treatment groups (n = 10)

	Median Ab titer	Testosterol (&mgr;g/mL)	Testis weight (g)
Control	1:100	20.3 ± 4.7	4.5 ± 0.9
Treatment	1:1600b	4.7 ± 0.8b	3.1 ± 1.1b

^bP < 0.01 vs control group.

Table 2 Influence of GnRH-PE40 intraperitoneal injection on sexual behavior of male rats (n = 10, mean ± SD)

	Latency(s) of			Number
	Mount	Intromission	Ejaculation	Mount	Intromission	Ejaculation
Control	31 ± 10	64 ± 21	605 ± 107	41 ± 13	27 ± 5	2.4 ± 0.6
Treatment	105 ± 43b	300 ± 27b	> 1800	20 ± 6b	8 ± 3b	0

^bP < 0.01 vs control group.