Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index

Table 1 Characteristics of cases and controls

	Controls/cases	OR 95% CI
Sex
Male	101/70	1
Female	98/67	0.986 (0.638-1.524)
Age (yr)
≤ 60	98/60	1
> 60	101/77	1.245 (0.804-1.928)
Smoking status
Non-smoker	147/75	1
Smoker	52/62	2.337 (1.473-3.708)b
Alcohol duration (yr)
Never	168/103	1
1-15	16/14	1.427 (0.669-3.046)
> 15	15/20	2.175 (1.066-4.437)
Body mass index (kg/m2)
18.5-22.9	101/35	1
23-24.9	38/54	4.101 (2.329-7.220)
> 25	60/48	2.309 (1.345-3.962)d

^bP < 0.001 vs non-smoker group (two-sided χ² test):

^dP < 0.001 vs normal BMI group (two-sided χ² test).

Table 2 COX-2 -765G>C genotypes and risk of CRC

	Controls/cases	OR1 95% CI
COX-2 genotype
GG	169/119	1
GC	29/17	0.867 (0.461-1.632)
CC	1/1

¹OR for GC/CC genotypes versus GG genotype and adjusted for age, gender, smoking status, alcohol consumption and body mass index.

Table 3 Relationship between C-1562T and R279Q genotypes and clinicopathological features of CRC

	-765G>C GG/GC+CC	OR1 95% CI
Age (yr)
< 60	49/11	1
≥ 60	70/7	0.445 (0.161-1.230)
Sex
Male	60/10	1
Female	59/8	0.814 (0.300-2.204)
Lymph node metastasis
N(-) (n = 87)	75/12	1
N(+)	41/5	0.762 (0.251-2.314)
TNM classification
StageI	22/4	1
> Stage II	94/13	0.761 (0.226-2.558)
External membrane invasion
(+)	91/11	1
(-)	25/6	1.985 (0.668-5.898)

¹The data were analyzed by Fisher′s exact test.

Table 4 COX-2 genotypes and risk for CRC in association with smoking status, alcohol duration and BMI

	-765GG		-765GC+CC
	Controls/cases	OR (95% CI)	Controls/cases	OR (95% CI)
Smoking status
Never	126/68	1	21/7	1
Smoker	43/51	2.682 (1.336-5.385)b	9/11	7.963 (0.615-103.051)
Alcohol duration (yr)
Never	143/89	1	25/14	1
1-15	13/12	0.750 (0.303-1.855)	3/2	0.713 (0.044-11.599)
> 15	13/18	0.810 (0.259-2.531)	2/2	0.199 (0.005-7.669)
Body mass index (BMI)
18.5-22.9	86/31	1	15/4	1
23-24.9	32/46	3.909 (2.081-7.344)	6/8	5.128 (0.867-30.320)
> 25	51/42	2.031 (1.107-3.726)d	9/6	6.281 (0.864-45.631)

^bP = 0.006 vs non-smoker group,

^dP < 0.001 vs normal BMI group (All estimates are multivariate adjusted for age, gender, smoking status, alcohol consumption and body mass index).