Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis

Table 1 Comparison of the degree of NFAT2 nucleo-translocation in LPMCs in patients of UC, CD and non-specific colitis

Grades of NFAT2 nucleo-translocation in LPMCs (%)	Ulcerative colitis (cases) (%)1	Crohn’s disease (cases) (%)1	Non-specific colitis (cases) (%)1
I (0)	2 (01.9)	6 (40.0)	23 (47.9)
II (< 10)	11 (10.3)	3 (20.0)	17 (35.4)
III (10-50)	13 (12.1)	2 (13.3)	4 (8.3)
IV (50-90)	20 (18.7)	1 (06.7)	4 (8.3)
V (> 90)	61 (57.0)	3 (20.0)	0 (0.00)
Total cases	107	15	48

¹P = 0.000 amongst UC, CD and NC groups, via Kruskal-Wallis statistics; P = 0.000 for UC vs CD, via Mann-Whitney’s test; P = 0.000 for UC vs NC, via Mann-Whitney’s test; P = 0.023 for CD vs NC, via Mann-Whitney’s test.

Table 2 Correlation of NFAT2 nucleotranslocation to clinical presentations

	P value	Statistic methods
Degree of NFAT2 nucleotranslocation1
Onset age (yr, mean ± SD)1	0.9484	t-test
Gender (M vs F) 1	0.651	χ2 test
Disease duration (< 3 m vs > 3 m) 1	0.507	χ2 test
Outcome (survived vs non-survived3)1	0.081	Fisher’s exact test
Outcome (colectomy vs non-colectomy)1	0.164	Fisher’s exact test
Degree of NFAT2 nucleotranslocation2
Endoscopic grade (1-4)2	0.0281	Kendall’s-rank correlation coefficient τ = 0.2145
Histological grade (1-4)2	0	Kendall’s-rank correlation coefficient τ = 0.4167

¹The degree of NFAT2 nucleo-translocation is divided into < 50% vs > 50% of LPMCs.

²The degree of NFAT2 nucleo-translocation is categorized into 0%, < 10%, 10%-50%, 50%-90%, > 90% of LPMCs.

³Non-survived: Died of complications of UC.