DNA methylation in hepatocellular carcinoma

Table 1 Methylation in hepatocellular carcinoma

Gene	Location	Function	Methylation frequency (%)	Ref.
p16INK4a	9q21	CDK inhibitor	17-83	[10,11]
p14ARF	9q21	MDM2 inhibitor	25-30	[7,12]
CASP8	2q33	Apoptosis	72	[17]
TMS1/ASC	16p11.2	Apoptosis	80	[23]
E-Cadherin	16q22.1	Cell adhesion	33-67	[28-30]
M-Cadherin	16q24.1	Cell adhesion	55	[34]
H-Cadherin	16q24.2-3	Cell adhesion	21	[17]
TIMP3	22q12	MMP inhibitor	13-19	[37-39]
hMLH1	3p21.3	Mismatch repair	18-44	[47-50]
hMSH2	2p21-22	Mismatch repair	68	[47,49,50]
hMSH3	5q11-12	Mismatch repair	75	[47,49,50]
MGMT	10q26	DNA repair	22-39	[53-55]
GSTP1	11q13	Detoxification	41-58	[53,58-61]
SOCS-1	16p13.13	Cytokine inhibitor	60	[67]
SOCS-3	17q25.3	Cytokine inhibitor	33	[68]
RASSF1A	3p21.3	Apoptosis	54-95	[71,75,76]
BLU	3p21.3	Unknown	20	[71]
SEMA3B	3p21.3	Apoptosis	80	[71]
FHIT	3p14.2	histidine triad protein	71	[86]