Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model

Table 1 Serum biochemical values in fibrotic rats induced by TAA treated with tetrandrine for 4 wk

Group	AST (IU/L)	ALT (IU/L)	T-Bil (μmol/L)
Normal	102 ± 24	34 ± 11	11.10 ± 1.29
TAA (200 mg/kg)	356 ± 70	198 ± 32	18.63 ± 2.50
TAA + tetrandrine (5 mg/kg)	266 ± 38a	142 ± 29b	15.70 ± 1.42a
TAA + tetrandrine (10 mg/kg)	259 ± 45a	139 ± 29b	15.11 ± 2.26b
TAA + tetrandrine (20 mg/kg)	227 ± 49d	115 ± 30d	14.89 ± 0.89b
TAA + interferon-г (5 × 104 U)	265 ± 38a	137 ± 25b	15.43 ± 1.36a

^aP < 0.05;

^bP < 0.01;

^dP < 0.001, vs control group.