Copyright
©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 21, 2007; 13(7): 1090-1097
Published online Feb 21, 2007. doi: 10.3748/wjg.v13.i7.1090
Published online Feb 21, 2007. doi: 10.3748/wjg.v13.i7.1090
No. | Locus | Markers | Genetic map(cM) | Forward | Reverse | PCR productsize (bp) | result1 |
1 | 8p23.3 | D8S7 | Not listed | ACCCTGACAGCAGAGGTTTC | ACCCTGACGTTCTCCCAGTA | 250-252 | ni |
2 | 8p23.2 | D8S1164 | Not listed | CACAAATCAGATTTTTGAAGTTGC | GGGTTAGACGGACAACCTCA | 225 | ni |
3 | 8p23.2 | D8S264 | 0.7 | ACATCTGCGTCGTCTTCATA | CCAACACCTGAGTCAGCATA | 121-145 | in |
4 | 8p23.2 | D8S262 | 4.3 | AGCTCAAAAGCGAAGGTGAT | GGCAACAAAGTGAGATCCTG | 114-128 | in |
5 | 8p23.1 | sts-X53793 | Not listed | TCGACTACCCAGTGGTCTTG | GTTCAAAATGCTTGCTCGC | 127 | ni |
6 | 8p23.1 | D8S1742 | Not listed | CCCCCACCAAGACACA | CTCAAGGGATATGAAGGGCA | 130 | in |
7 | 8p23.1 | D8S277 | 8.2 | GATTTGTCCTCATGCAGTGT | ACATGTTATGTTTGAGAGGTCTG | 121 | in |
8 | 8p23.1 | D8S1918 | Not listed | GAATGTCATGCTGGGAACG | GTAGCTCTCAAAGCAAATTATGAGC | 108 | ni |
9 | 8p23.1 | D8S1819 | 10 | TCACTGAGGGACTTGGC | CGTGCTGAGAATGAGACC | 207 | in |
10 | 8p23.1 | D8S1140 | Not listed | GACAACATCCGATAATGCTG | GAGGACATCTAGATAATTGGAAGA | 378 | ni |
11 | 8p23.1 | D8S503 | 16.2 | GGTTACGAGTTTTGTCCTTTG | GAAACAAACCAATGTAGGAGTG | 136 | in |
12 | 8p23.1 | D8S1672 | Not listed | AACTGAGATCACGCCACTCC | CCCATTGGTTTTAGAGTGGC | 149 | ni |
13 | 8p23.1 | AFM234ve1 | Not listed | TACCGCAAAACACACCA | GCAGCCTTAGTTGACAACA | 245 | ni |
14 | 8p23.1 | D8S2045 | Not listed | CCGATTGCTTCATCGGGAC | CGCCTCCTCCTCTGAAATCCT | 120 | ni |
15 | 8p23.1 | D8S1130 | 22.4 | GAAGATTTGGCTCTGTTGGA | TGTCTTACTGCTATAGCTTTCATAA | 145 | in |
16 | 8p23.1 | D8S1946 | Not listed | GCACAAGATCAGAGAGGTTGTG | GAGGAGAGATGGTGTTGGGA | 102 | ni |
17 | 8p23.1 | D8S1640 | Not listed | TGCAGTCTGCGGGAGTTC | AGCAGGGTGACTGTAAAGAAGG | 175 | ni |
18 | 8p23.1 | D8S2060 | Not listed | CTCTCCGGGAATGTAATACTGC | GAGCTGGGAGTTACTGCCTG | 256 | ni |
19 | 8p23.1 | D8S552 | 26.4 | CCTGTACCATACCCCTGTATC | AAGGTTTGAATCTCTCAGTGG | 132 | in |
20 | 8p23.1 | D8S1109 | 26.4 | TTCTCAGAATTGCTCATAGTGC | TCAGCTCCTCTTCTGCTGAT | 241 | in |
21 | 8p23.1 | D8S2066 | Not listed | TTTTCTCCATCCGGTGACTC | CCAACTACGGCATGGTTTCT | 175 | ni |
22 | 8p23.1-22 | D8S1106 | 26.5 | TTGTTTACCCCTGCATCACT | TTCTCAGAATTGCTCATAGTGC | 149 | ni |
23 | 8p22 | D8S1451 | Not listed | AACCTAAGGTTCTGTGCTACATCA | AACTTACCAAGGCCGTTTAGG | 149 | ni |
24 | 8p22 | EST465487 | Not listed | TTTGTTTGGGTGGAGGACTC | TGGACATCTGCCTAGGTCCT | 250 | ni |
25 | 8p22 | D8S1647 | Not listed | CCAGAATTTTGAAATAGATTCATCC | AAATTTTGTAAATATCAGTGTTCCG | 174 | ni |
26 | 8p22 | stSG29388 | 32 | GCAGTGAGATTTTGCTTCTGG | ATGAACATTCAATGAATCAGCA | 125 | ni |
27 | 8p22 | D8S1713 | Not listed | CAGGGGCTGATTGTCAGAAC | GTGGCTGTCACCAAGGTCTC | 113 | ni |
28 | 8p22 | SGC33312 | Not listed | AGGGCCTTGGGAACACTC | TCAGTTTAAATGGATGGTTTTTACT | 137 | ni |
29 | 8p22 | D8S2080 | Not listed | GACTCAAAGAGAACCTGCCG | TAGGTTGGTGAGCACACGTC | 132 | ni |
30 | 8p22 | D8S2081 | Not listed | ACCCAGTTACAGCACTGTAATATCA | CTCTACCCCGAAATGATGGA | 147 | ni |
31 | 8p22 | SHGC-24261 | Not listed | AAGCAGAGATAAGCCCGACA | TTTCTTTAGATGGAGTCCATTGC | 123 | ni |
32 | 8p22 | SHGC-52401 | Not listed | ACAGGATAGTGTTAGGCTCACATG | CATTCTCTGTATCTTTTGGGGG | 120 | ni |
33 | 8p22 | D8S254 | Not listed | TGCCGGACATACATTAGTGA | TTGTAAACACCACAAGCAGG | 65-75 | in |
34 | 8p22 | D8S2001 | Not listed | GACATTGAATTCCAGTATTTGTGC | GGACAAATGCCACTGCAAC | 138 | ni |
35 | 8p22 | SHGC-5873 | Not listed | GACACACACATACAGAAAACCA | CTTACCATGAATGGAGCTTG | 225 | ni |
36 | 8p22 | D8S261 | 35.8 | TGCCACTGTCTTGAAAATCC | TATGGCCCAGCAATGTGTAT | 128 | in |
37 | 8p22 | AFM234vf4 | Not listed | GGGCACAGGCATGTGT | GGCTGCATTCTGAAAGGTTA | 260-272 | ni |
38 | 8p22 | D8S1948 | Not listed | TTACAAAACATACCCAGTGTTTGG | CTTTTTAGTGCTTGAGACTGTCTCC | 110 | ni |
39 | 8p22 | D8S2028 | Not listed | TCAAAAGTTTTGTTTCTATTCAGGG | TTTTTTCTGTTCCCCTCCG | 178 | ni |
40 | 8p22 | D8S258 | 40.3 | CTGCCAGGAATCAACTGAG | TTGACAGGGACCCACG | 144-154 | in |
41 | 8p22 | D8S1949 | Not listed | TGTCTTACAGCTCTCCCTCTCC | CAGTAAGGATCACCAAGACAAGG | 106 | ni |
42 | 8p22 | D8S1983 | Not listed | ATTGGAAGAGGCAAATGGTG | TATGTACTGGATGAAGCAGGACA | 175 | ni |
43 | 8p22 | D8S1786 | Not listed | CGAAAGATTGAGACCCCAT | GTTTCCACACCGAAGCC | 209 | ni |
44 | 8p22 | D8S298 | 42.7 | AGGCTTACACCCATGGACC | ACGCAGCACACAACATCAT | 155-167 | in |
45 | 8p21.3 | D8S2050 | Not listed | TGCCAATATCAGTGGAAGAGG | TCCTTTTTCCCTTGTTGCC | 162 | ni |
46 | 8p21.3 | D8S1752 | Not listed | TCCTGGATCAGGCAGAAA | TCAGAGTTGGGTGAGCGA | 140 | in |
47 | 8p21.3 | D8S1734 | 44.9 | GCTATCCACTTGTCCCAGA | AGCCCAGAAATAAACCCTC | 114 | in |
48 | 8p21.2 | D8S2256 | Not listed | GTGTCTTGAGATACTGGTGA | GAGAAATGTCTTTGTTGAGG | 101 | ni |
49 | 8p21.2 | D8S2259 | Not listed | TGAAAGCCTGTTTAGAGAGA | CTATTGCCCTGTGTTTTGCC | 105 | ni |
50 | 8p21.2 | D8S1220 | Not listed | TTCCGTATACACATGCACCC | TAGCAGCCAGACACAGGAGC | 90 | ni |
51 | 8p21.1 | D8S1445 | Not listed | GCAACAGAGCGAGACTCCGTC | AAGCTTACATTCTGGGTGAC | 117-139 | in |
52 | 8p21.1 | D8S2261 | Not listed | GTATTTATTCCACAAGCATCTTA | CAACCCCATCAGTCTCTCTAAT | 204 | ni |
53 | 8p21.1 | D8S1444 | Not listed | TTCTTCTAGATTTCCTACTA | CATTTGTTAAAAGTACAACC | 91 | x |
54 | 8p21 | D8S2249 | Not listed | TCCACCCATTTCAGCCTTTC | CTAAAACATTTAACTTTCATT | 101 | ni |
55 | 8p21 | D8S2248 | Not listed | ATACAGGTAGGTGAGGGCAA | TTCTGATGCTCTTCTGGAGT | 136 | ni |
56 | 8p21 | D8S2247 | Not listed | CATTGTGGTGGAGGTCGGAG | TTCCCCCATCCCATCTGAG | 122 | ni |
57 | 8p21 | D8S2262 | Not listed | ATGTTTTGTTCATGGGTCTTT | AAGAAAAAGGGAAGGGGCAGT | 98 | ni |
58 | 8p21 | D8S339 | Not listed | TAGATGTTACCATTTCAC | GATTAGATCTTGGATCAG | 162 | ni |
59 | 8p21 | D8S2245 | Not listed | CCTCTTTATCCCACTTTTCAG | CATTTTACGAATATAAGCATCC | 138 | ni |
60 | 8p21 | D8S2244 | Not listed | ACAACTAAAGGACTTAAAGG | GACAAGAAAAGAACAAATGG | 145 | ni |
61 | 8p21 | D8S2246 | Not listed | TAACCTGTGAATGAGAATAC | TGACAGTTTTGAGAGAATCC | 169 | ni |
Case | Age | Sex | St/Mt | Grading | Etiology | D8S264 | D8S262 | 8p23.2 | D8S1742 | D8S277 | D8S1819 | D8S503 | D8S1130 | D8S552 | D8S1109 | 8p23.1 | D8S254 | D8S261 | D8S258 | D8S298 | 8p22 | D8S1752 | D8S1734 | D8S1445 | 8p21 | 8p23.2-21 |
12 | 60 | M | Mt | MD | Alcoholic | ni | ni | ni | ni | ni | ni | ni | ○ | ni | ni | ○ | ○ | ○ | ● | ○ | ● | ○ | ○ | ○ | ○ | ● |
11 | 64 | M | St | MD | CH(C)+, LC | ni | ni | ni | ○ | ○ | ni | ○ | ○ | ni | ○ | ○ | ○ | ni | ● | ni | ● | ○ | ○ | ○ | ○ | ● |
1 | 42 | M | St | PD | CH(B)+ | ni | ni | ni | ni | ○ | ○ | ni | ○ | ni | ● | ● | ● | ○ | ni | ni | ● | ○ | ○ | ○ | ○ | ● |
2 | 59 | M | St | MD | CH(-) | ○ | ○ | ○ | ni | ni | ni | ○ | ○ | ni | ● | ● | ● | ○ | ni | ○ | ● | ni | ○ | ○ | ○ | ● |
27 | 69 | M | Mt | PD | CH(C)+ | ni | ni | ni | ○ | ○ | ni | ni | ni | ni | ● | ● | ○ | ○ | ○ | ni | ○ | ○ | ○ | ○ | ○ | ● |
26 | 58 | M | St | MD | CH(C)+, LC | ○ | ni | ○ | ○ | ○ | ○ | ● | ○ | ni | ○ | ● | ○ | ○ | ni | ○ | ○ | ○ | ni | ○ | ○ | ● |
15 | 31 | F | Mt | MD | CH(C)+ | ni | ni | ni | ni | ni | ni | ● | ni | ni | ni | ● | ni | ni | ● | ni | ● | ○ | ni | ○ | ○ | ● |
29 | 73 | M | St | WD | CH(C)+ | ni | ni | ni | ni | ni | ni | ni | ● | ni | ○ | ● | ● | ni | ● | ● | ● | ○ | ○ | ○ | ○ | ● |
6 | 72 | M | St | MD | CH(C)+ | ni | ni | ni | ni | ni | ○ | ni | ● | ni | ni | ● | ○ | ni | ● | ○ | ● | ○ | ○ | ○ | ○ | ● |
20 | 65 | M | St | WD | Alcoholic, LC | ni | ○ | ○ | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ni | ● | ● | ○ | ○ | ● | ● |
8 | 74 | M | Mt | MD | CH(-) | ni | ○ | ○ | ● | ● | ni | ni | ● | ni | ○ | ● | ● | ni | ni | ● | ● | ● | ni | ni | ● | ● |
7 | 59 | M | Mt | WD | CH(B)+, (C)+ | ○ | ○ | ○ | ○ | ● | ● | ni | ● | ni | ni | ● | ○ | ni | ni | ○ | ○ | ○ | ● | ● | ● | ● |
19 | 50 | M | Mt | MD | CH(B)+, LC | ○ | ● | ● | ● | ○ | ni | ● | ● | ● | ○ | ● | ni | ni | ● | ○ | ● | ● | ● | ○ | ● | ● |
28 | 58 | M | Mt | MD | CH(B)+ | ni | ○ | ○ | ni | ○ | ni | ○ | ● | ● | ○ | ● | ● | ni | ni | ni | ● | ni | ○ | ○ | ○ | ● |
5 | 51 | M | Mt | MD | CH(B)+ | ni | ni | ni | ni | ni | ○ | ni | ● | ni | ni | ● | ● | ni | ni | ni | ● | ni | ○ | ○ | ○ | ● |
10 | 71 | F | Mt | MD | CH(C)+, LC | ni | ni | ni | ○ | ○ | ○ | ● | ni | ni | ni | ● | ● | ○ | ● | ni | ● | ○ | ○ | ○ | ○ | ● |
4 | 57 | M | Mt | MD | CH(C)+, LC | ○ | ○ | ○ | ni | ● | ○ | ○ | ○ | ○ | ○ | ● | ○ | ni | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ● |
13 | 74 | M | Mt | MD | CH(-) | ni | ni | ni | ○ | ni | ni | ni | ● | ni | ni | ● | ni | ni | ni | ni | ni | ○ | ni | ○ | ○ | ● |
18 | 51 | M | St | WD | CH(B)+, LC | ni | ni | ni | ni | ni | ○ | ni | ni | ○ | ni | ○ | ● | ○ | ni | ni | ● | ○ | ○ | ○ | ○ | ● |
16 | 54 | M | Mt | MD | Alcoholic, LC | ni | ni | ni | ○ | ni | ni | ○ | ○ | ni | ni | ○ | ● | ni | ○ | ni | ● | ○ | ni | ○ | ○ | ● |
25 | 71 | M | St | MD | CH(B)+, (C)+ | ni | ○ | ○ | ○ | ni | ni | ni | ○ | ni | ni | ○ | ni | ni | ni | ni | ni | ○ | ni | ○ | ○ | ○ |
30 | 56 | M | St | MD | CH(C)+ | ni | ○ | ○ | ○ | ○ | ni | ○ | ni | ni | ○ | ○ | ni | ni | ni | ○ | ○ | ni | ni | ○ | ○ | ○ |
9 | 57 | M | St | WD | CH(C)+ | ni | ni | ni | ○ | ni | ni | ni | ○ | ni | ni | ○ | ○ | ni | ni | ni | ni | ○ | ○ | ○ | ○ | ○ |
3 | 51 | M | St | MD | CH(B)+ | ni | ni | ni | ○ | ○ | ○ | ni | ○ | ni | ○ | ○ | ○ | ni | ○ | ni | ○ | ni | ○ | ○ | ○ | ○ |
32 | 54 | F | St | MD | CH(B)+, LC | ○ | ni | ○ | ○ | ○ | ni | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ni | ○ | ○ | ○ | ○ | ○ | ○ |
21 | 67 | M | St | WD | CH(C)+, LC | ni | ni | ni | ni | ○ | ni | ni | ni | ni | ni | ○ | ni | ni | ○ | ○ | ○ | ni | ni | ○ | ○ | ○ |
33 | 76 | F | St | WD | CH(C)+, LC | ○ | ○ | ○ | ○ | ni | ni | ni | ○ | ni | ○ | ○ | ○ | ni | ni | ○ | ○ | ○ | ○ | ○ | ○ | ○ |
23 | 71 | M | Mt | MD | CH(-) | ni | ni | ni | ni | ni | ni | ni | ○ | ni | ni | ○ | ni | ni | ○ | ni | ○ | ni | ○ | ○ | ○ | ○ |
22 | 65 | M | Mt | MD | CH(C)+ | ni | ni | ni | ni | ni | ○ | ni | ni | ni | ni | ○ | ○ | ni | ni | ○ | ○ | ○ | ○ | ○ | ○ | ○ |
31 | 65 | F | Mt | MD | CH(C)+, LC | ni | ni | ni | ○ | ni | ○ | ni | ○ | ○ | ○ | ○ | ni | ni | ni | ni | ni | ni | ○ | ○ | ○ | ○ |
17 | 37 | F | Mt | MD | CH(B)+, LC | ni | ni | ni | ni | ni | ni | ni | ni | ni | ni | ni | ni | ○ | ni | ni | ○ | ni | ni | ○ | ○ | ○ |
24 | 60 | M | Mt | MD | CH(-), LC | ni | ○ | ○ | ni | ○ | ni | ni | ni | ni | ○ | ○ | ○ | ni | ○ | ni | ○ | ○ | ○ | ○ | ○ | ○ |
LOH ● | 0 | 1 | 1 | 3 | 4 | 2 | 5 | 9 | 3 | 4 | 16 | 10 | 1 | 8 | 2 | 15 | 3 | 2 | 1 | 4 | 20 | |||||
Informative (32/33) | 8 | 13 | 16 | 17 | 16 | 12 | 12 | 23 | 7 | 17 | 31 | 23 | 10 | 16 | 13 | 32 | 23 | 23 | 31 | 32 | 32 | |||||
LOH/Informative (58/264 = 22%) | 0% | 8% | 6%a | 18% | 25% | 17% | 42% | 39% | 43% | 24% | 52%b | 43% | 10% | 50% | 15% | 47%c | 13% | 9% | 3% | 13%d | 63%e |
ClinicopathologicalVariables | D8S264 | D8S262 | 8p23.2 | D8S1742 | D8S277 | D8S1819 | D8S503 | D8S1130 | D8S552 | D8S1109 | 8p23.1 | D8S254 | D8S261 | D8S258 | D8S298 | 8p22 | D8S1752 | D8S1734 | D8S1445 | 8p21 | 8p23.2-21 |
Tumor size (mm) | |||||||||||||||||||||
> 50 | 0/4 | 0/4 | 0/5 (0%) | 0/6 | 1/5 | 0/6 | 2/4 | 4/12 | 0/1 | 3/8 | 10/14 (71%) | 4/10 | 0/5 | 3/7 | 1/6 | 6/13 (46%) | 0/10 | 0/10 | 0/15 | 0/15 (0%) | 10/15 (67%) |
< 50 | 0/3 | 1/7 | 1/8 (13%) | 3/11 | 3/11 | 2/6 | 3/7 | 5/11 | 3/6 | 1/9 | 6/17 (35%) | 6/13 | 1/7 | 5/9 | 1/7 | 9/16 (56%) | 3/11 | 2/14 | 1/15 | 4/15 (27%) | 10/17 (59%) |
Tumor number | |||||||||||||||||||||
St | 0/2 | 0/3 | 0/5 (0%) | 1/9 | 1/8 | 1/5 | 2/6 | 3/12 | 1/3 | 3/10 | 6/15 (41%) | 9/18 | 1/6 | 4/7 | 1/7 | 4/13 (31%) | 3/20 | 2/18 | 1/24 | 4/24 (17%) | 17/24 (71%) |
Mt | 0/5 | 1/10 | 1/10 (10%) | 2/7 | 3/8 | 1/6 | 3/6 | 6/11 | 2/4 | 1/7 | 10/16 (63%) | 1/4 | 0/4 | 4/9 | 1/6 | 5/13 (38%) | 0/2 | 0/5 | 0/7 | 0/7 (0%) | 2/7 (29%) |
Growth Pattern | |||||||||||||||||||||
Eg | 0/8 | 1/13 | 1/15 (7%) | 3/16 | 4/13 | 2/11 | 4/11 | 9/22 | 3/7 | 3/15 | 14/28 (50%) | 8/20 | 1/8 | 7/14 | 2/13 | 13/26 (50%) | 3/20 | 2/21 | 1/29 | 4/29 (14%) | 18/29 (62%) |
Ig | 0/1 | 0/1 | 0/1 (0%) | 0/1 | 0/3 | 0/2 | 1/1 | 0/1 | 0/0 | 1/2 | 2/5 (40%) | 2/2 | 0/2 | 1/2 | 0/0 | 2/2 (100%) | 0/2 | 0/2 | 0/2 | 0/2 (0%) | 2/2 (100%) |
Formation of capsule | |||||||||||||||||||||
Fc- | 0/6 | 1/8 | 1/10 (10%) | 2/3 | 1/4 | 1/4 | 2/3 | 4/7 | 3/4 | 2/5 | 5/6 (83%) | 3/4 | 1/3 | 3/3 | 0/3 | 5/5 (100%) | 2/5 | 1/5 | 0/5 | 2/5 (40%) | 5/5 (100%) |
Fc+ | 0/2 | 0/6 | 0/6 (0%) | 1/14 | 3/12 | 1/8 | 3/9 | 5/17 | 0/3 | 2/12 | 11/25 (44%) | 7/18 | 0/7 | 5/13 | 2/10 | 10/23 (43%) | 1/18 | 1/18 | 1/26 | 2/26 (8%) | 15/26 (58%) |
Infiltration to capsule | |||||||||||||||||||||
Fc-Inf- | 0/6 | 1/8 | 1/10 (10%) | 1/5 | 1/7 | 0/7 | 3/5 | 3/8 | 0/4 | 2/8 | 7/11 (64%) | 3/10 | 0/5 | 4/9 | 0/3 | 7/15 (47%) | 1/10 | 1/12 | 0/15 | 1/15 (7%) | 10/15 (67%) |
Fc-Inf+ | 0/1 | 0/3 | 0/3 (0%) | 1/8 | 1/3 | 0/2 | 1/4 | 3/10 | 0/0 | 1/5 | 5/13 (38%) | 5/9 | 0/3 | 3/5 | 2/7 | 6/11 (55%) | 1/10 | 0/8 | 0/13 | 1/13 (8%) | 7/13 (54%) |
Septal formation | |||||||||||||||||||||
Sf- | 0/0 | 0/3 | 0/3 (0%) | 1/7 | 2/6 | 1/7 | 3/5 | 3/8 | 1/4 | 2/5 | 7/13 (54%) | 5/9 | 0/5 | 5/9 | 1/4 | 7/15 (47%) | 1/12 | 0/12 | 0/16 | 1/16 (6%) | 9/16 (56%) |
Sf+ | 0/6 | 1/9 | 1/10 (10%) | 2/8 | 1/5 | 0/3 | 1/4 | 3/10 | 1/1 | 2/7 | 5/12 (42%) | 4/10 | 0/3 | 3/6 | 1/6 | 7/11 (64%) | 2/9 | 1/9 | 0/12 | 2/12 (17%) | 8/12 (67%) |
Grading | |||||||||||||||||||||
WD | 0/3 | 0/3 | 0/4 (0%) | 1/4 | 2/4 | 2/4 | 1/2 | 4/6 | 1/4 | 1/2 | 4/8 (50%) | 3/6 | 1/2 | 3/5 | 1/5 | 3/7 (43%) | 1/7 | 1/7 | 1/7 | 2/7 (29%) | 4/7 (57%) |
MD | 1/7 | 0/9 | 1/13 (8%) | 2/13 | 2/12 | 1/9 | 4/12 | 5/17 | 1/12 | 3/6 | 11/21 (52%) | 6/13 | 1/8 | 5/11 | 1/13 | 10/18 (56%) | 2/12 | 1/13 | 0/21 | 2/21 (10%) | 13/21 (62%) |
PD | 0/0 | 0/1 | 0/1 (0%) | 0/1 | 0/3 | 0/1 | 0/1 | 1/3 | 2/3 | 0/1 | 2/3 (67%) | 1/2 | 1/3 | 0/1 | 0/0 | 1/2 (50%) | 0/2 | 0/2 | 0/2 | 0/2 (0%) | 2/2 (100%) |
pT | |||||||||||||||||||||
pT1 | 0/1 | 0/2 | 0/2 (0%) | 0/2 | 0/1 | 0/1 | 0/1 | 1/2 | 0/3 | 0/2 | 0/5 (0%) | 2/6 | 0/1 | 2/3 | 1/2 | 3/6 (50%) | 0/6 | 0/6 | 0/6 | 0/6 (0%) | 3/6 (50%) |
pT2 | 1/7 | 0/7 | 1/10 (10%) | 2/6 | 1/7 | 1/3 | 4/6 | 4/5 | 2/5 | 3/3 | 7/11 (64%) | 5/8 | 1/4 | 5/7 | 0/4 | 7/11 (64%) | 2/8 | 1/9 | 0/11 | 2/11 (18%) | 8/11 (73%) |
pT3 | 0/2 | 0/2 | 0/3 (0%) | 1/4 | 2/2 | 1/3 | 0/2 | 3/8 | 1/5 | 0/1 | 5/8 (63%) | 2/4 | 0/1 | 0/2 | 1/4 | 2/5 (40%) | 1/5 | 1/5 | 1/8 | 2/8 (25%) | 5/8 (63%) |
pT4 | 0/0 | 0/0 | 0/0 (0%) | 0/0 | 0/1 | 0/1 | 0/0 | 0/1 | 1/1 | 0/0 | 1/1 (100%) | 1/1 | 0/2 | 0/0 | 0/0 | 1/2 (50%) | 0/1 | 0/1 | 0/2 | 0/2 (0%) | 1/2 (50%) |
pN | |||||||||||||||||||||
pN- | 1/8 | 0/10 | 1/12 (8%) | 3/7 | 3/7 | 2/4 | 3/5 | 6/9 | 1/8 | 0/1 | 5/12 (42%) | 4/9 | 0/0 | 6/7 | 2/7 | 8/13 (62%) | 3/11 | 2/10 | 1/13 | 4/13 (31%) | 9/13 (69%) |
pNx | 0/0 | 0/3 | 0/3 (0%) | 0/6 | 1/5 | 0/4 | 1/4 | 2/9 | 2/6 | 1/5 | 6/12 (50%) | 2/4 | 0/6 | 1/5 | 0/1 | 2/4 (50%) | 0/5 | 0/5 | 0/7 | 0/7 (0%) | 4/7 (57%) |
pM | |||||||||||||||||||||
pM- | 1/6 | 0/11 | 1/13 (8%) | 2/7 | 1/5 | 1/2 | 3/5 | 3/10 | 3/8 | 2/4 | 6/14 (43%) | 3/7 | 1/5 | 5/9 | 1/6 | 6/11 (55%) | 2/10 | 1/11 | 0/13 | 2/13 (15%) | 7/13 (54%) |
pMx | 0/0 | 0/0 | 0/0 (0%) | 0/0 | 2/3 | 0/2 | 0/1 | 2/2 | 0/2 | 1/1 | 3/4 (75%) | 5/6 | 0/1 | 0/1 | 0/0 | 5/7 (71%) | 1/5 | 0/5 | 0/8 | 1/8 (13%) | 7/8 (88%) |
Vascular infiltration | |||||||||||||||||||||
V- | 0/7 | 1/10 | 1/13 (8%) | 2/10 | 3/10 | 1/8 | 4/9 | 6/13 | 2/6 | 2/9 | 9/20 (45%) | 6/15 | 0/5 | 7/13 | 0/7 | 11/20 (55%) | 2/16 | 2/18 | 1/21 | 3/21 (14%) | 14/21 (67%) |
V+ | 1/7 | 0/2 | 1/9 (11%) | 1/7 | 1/6 | 1/4 | 1/3 | 3/10 | 1/1 | 2/8 | 7/11 (64%) | 4/6 | 1/5 | 1/3 | 2/6 | 4/7 (57%) | 1/6 | 0/5 | 0/9 | 1/9 (11%) | 5/9 (56%) |
Bile duct infiltration | |||||||||||||||||||||
B- | 0/10 | 1/13 | 1/17 (6%) | 3/18 | 4/15 | 2/11 | 4/13 | 10/24 | 3/9 | 3/17 | 15/28 (54%) | 7/18 | 2/9 | 8/15 | 2/12 | 11/24 (46%) | 2/19 | 2/20 | 1/27 | 3/27 (11%) | 16/27 (59%) |
B+ | 0/1 | 0/1 | 0/2 (0%) | 0/3 | 0/3 | 1/4 | 1/3 | 0/4 | 1/3 | 1/4 | 3/4 (75%) | 3/5 | 1/5 | 0/1 | 0/4 | 4/5 (80%) | 1/4 | 0/4 | 0/5 | 1/5 (20%) | 4/5 (80%) |
Liver cirrhosis | |||||||||||||||||||||
LC- | 0/2 | 0/6 | 0/6 (0%) | 1/8 | 2/7 | 1/6 | 1/4 | 7/14 | 1/1 | 3/8 | 11/18 (61%) | 6/11 | 0/4 | 4/7 | 2/8 | 9/16 (56%) | 1/10 | 1/13 | 1/18 | 2/18 (11%) | 12/18 (67%) |
LC+ | 0/5 | 1/5 | 1/7 (14%) | 2/9 | 2/9 | 1/6 | 4/8 | 2/9 | 2/6 | 1/9 | 5/13 (38%) | 4/10 | 1/6 | 4/9 | 0/5 | 6/13 (46%) | 2/11 | 1/11 | 0/14 | 2/14 (14%) | 8/14 (57%) |
Chronic hepatitis | |||||||||||||||||||||
CH- | 0/1 | 0/3 | 0/4 (0%) | 2/3 | 2/3 | 1/1 | 1/2 | 3/7 | 1/1 | 2/4 | 4/8 (50%) | 4/6 | 1/3 | 2/5 | 1/3 | 5/7 (71%) | 2/6 | 0/5 | 0/8 | 2/8 (25%) | 6/8 (75%) |
CH+ | 0/6 | 1/7 | 1/9 (11%) | 1/13 | 2/13 | 1/11 | 4/9 | 6/16 | 2/6 | 2/13 | 12/23 (52%) | 6/17 | 0/7 | 6/11 | 1/10 | 10/22 (45%) | 1/17 | 2/19 | 1/24 | 2/24 (8%) | 14/24 (58%) |
- Citation: Lu T, Hano H, Meng C, Nagatsuma K, Chiba S, Ikegami M. Frequent loss of heterozygosity in two distinct regions, 8p23.1 and 8p22, in hepatocellular carcinoma. World J Gastroenterol 2007; 13(7): 1090-1097
- URL: https://www.wjgnet.com/1007-9327/full/v13/i7/1090.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i7.1090