Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases

doi:10.3748/wjg.v13.i5.785

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Feb 7, 2007 (publication date) through Apr 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2007; 13(5): 785-790
Published online Feb 7, 2007. doi: 10.3748/wjg.v13.i5.785

Table 1 Serum IGF-1, osteocalcin and PTH levels in patient groups and control group (mean ± SE)

	Control	Bilharziasis	HBV	HCV
	(n = 30)	(n = 9)	(n = 12)	(n = 29)
IGF-1 (ng/mL)	277.1 ± 12.2	94.0 ± 4.30^b	105.1± 10.3^b	230.0 ± 10.5^b
Osteocalcin (ng/mL)	5.7 ± 0.3	6.8 ± 0.66	16.5 ± 0.76^b	14.7 ± 0.54^b
PTH (ng/mL)	61.6 ± 2.7	63.3 ± 3.03	83.4 ± 4.30^b	70.1 ± 2.17^a

^aP < 0.05,

^bP < 0.01 vs control group.

Table 2 Liver function tests in different patient groups and control group (mean ± SE)

	Control	Bilharziasis	HBV	HCV
	(n = 30)	(n = 9)	(n = 12)	(n = 29)
ALT	20.5 ± 0.9	38.0 ± 6.8^a	72.6 ± 12.4^a	107.0 ± 28.1^a
(U/L)	20.5 ± 0.9	38.0 ± 6.8^a	72.6 ± 12.4^a	107.0 ± 28.1^a
AST	18.4 ± 0.8	46.0 ± 7.5^a	71.2 ± 10.8^a	120.0 ± 21.8^a
(U/L)	18.4 ± 0.8	46.0 ± 7.5^a	71.2 ± 10.8^a	120.0 ± 21.8^a
ALP	74.0 ± 9.3	82.0 ± 11.8	214.0 ± 41.2^a	165.0 ± 28.9^a
(U/L)	74.0 ± 9.3	82.0 ± 11.8	214.0 ± 41.2^a	165.0 ± 28.9^a
GGT	26.0 ± 2.1	37.6 ± 9.9	54.0 ± 1.5^a	59.9 ± 11.1^a
(U/L)	26.0 ± 2.1	37.6 ± 9.9	54.0 ± 1.5^a	59.9 ± 11.1^a
T. bilirubin	0.84 ± 0.03	0.9 ± 0.16	1.8 ± 0.20^a	1.3 ± 0.13^a
(mg/dL)	0.84 ± 0.03	0.9 ± 0.16	1.8 ± 0.20^a	1.3 ± 0.13^a
T. protein	6.9 ± 0.10	7.1 ± 0.30	6.8 ± 0.20	6.7 ± 0.10^a
(mg/dL)	6.9 ± 0.10	7.1 ± 0.30	6.8 ± 0.20	6.7 ± 0.10^a
Albumin	4.0 ± 0.06	3.9 ± 0.10	3.5 ± 0.19^a	3.6 ± 0.10^a
(mg/dL)	4.0 ± 0.06	3.9 ± 0.10	3.5 ± 0.19^a	3.6 ± 0.10^a
Prothrombin	93.0 ± 1.3	77.0 ± 4.0^a	69.0 ± 6.0^a	65.6 ± 2.50^a
(%)	93.0 ± 1.3	77.0 ± 4.0^a	69.0 ± 6.0^a	65.6 ± 2.50^a

^aP < 0.05 vs control group.

Table 3 Alterations in serum IGF-1, osteocalcin and PTH levels according to the severity of the disease from class A to C (mean ± SE)

Severity	A	B	C	LSD at 0.05
Severity	(n = 24)	(n = 22)	(n = 4)	LSD at 0.05
IGF-1	152.6^b± 7	186.8^a± 20.3	196.0^a± 36.4	32.67
(ng/mL)	152.6^b± 7	186.8^a± 20.3	196.0^a± 36.4	32.67
Osteocalcin	12.6^b± 0.9	14.6^a± 0.9	15.8^a± 1.2	1.73
(ng/mL)	12.6^b± 0.9	14.6^a± 0.9	15.8^a± 1.2	1.73
PTH	71.3^b± 3.0	70.3^b± 2.7	86.5^a± 4.3	5.36
(ng/mL)	71.3^b± 3.0	70.3^b± 2.7	86.5^a± 4.3	5.36

Within each row the means followed by different letters are significantly different. LSD: Least significance difference.

^aP < 0.05,

^bP < 0.01 vs control group.

Table 4 Effect of age and sex on serum IGF-1, osteocalcin and PTH (mean ± SE)

	Age (yr)			Sex
	3-9	10-16	P	Male	Female	P
IGF-1	153.2 ± 59.3	182.6 ± 84.5	0.268	175.2 ± 84.2	177.1 ± 58.4	0.948
(ng/mL)	153.2 ± 59.3	182.6 ± 84.5	0.268	175.2 ± 84.2	177.1 ± 58.4	0.948
Osteocalcin	13.8 ± 4.7	13.7 ± 4.2	0.941	13.1 ± 4.1	16.4^a± 4.1	0.037
(ng/mL)	13.8 ± 4.7	13.7 ± 4.2	0.941	13.1 ± 4.1	16.4^a± 4.1	0.037
PTH	71.1 ± 14.0	72.3 ± 13.8	0.786	73.1 ± 13.8	67.2 ± 13.1	0.249
(ng/mL)	71.1 ± 14.0	72.3 ± 13.8	0.786	73.1 ± 13.8	67.2 ± 13.1	0.249

^aP < 0.05 vs males.

Citation: Mahdy KA, Ahmed HH, Mannaa F, Abdel-Shaheed A. Clinical benefits of biochemical markers of bone turnover in Egyptian children with chronic liver diseases. World J Gastroenterol 2007; 13(5): 785-790
URL: https://www.wjgnet.com/1007-9327/full/v13/i5/785.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i5.785