Copyright
©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2007; 13(48): 6492-6497
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6492
Published online Dec 28, 2007. doi: 10.3748/wjg.v13.i48.6492
Table 1 Patient characteristics (mean ± SD)
Variables | All patients(n = 133) | Male(n = 83) | Female(n = 50) | P | ||
Age (yr) | 63.9 ± 7.0 | 64.3 ± 6.8 | 63.3 ± 7.4 | NS | ||
Duration after gastrectomy (yr) | 2.7 ± 2.4 | 2.8 ± 2.6 | 2.5 ± 2.2 | NS | ||
BMI (kg/m2) | 21.5 ± 3.3 | 21.7 ± 3.1 | 21.2 ± 3.7 | NS | ||
BMI change after gastrectomy (kg/m2) | –2.2 ± 2.4 | –2.0 ± 2.4 | –2.7 ± 2.3 | < 0.05 | ||
AGC/EGC (n) | 75/58 | 42/41 | 33/17 | NS | ||
TNM stage | 1 | 76 | 56 | 20 | < 0.05 | |
2 | 26 | 15 | 11 | |||
3 | 25 | 10 | 15 | |||
4 | 6 | 2 | 4 | |||
Operation type | Subtotal gastrectomy | Billroth I | 47 | 30 | 17 | NS |
Billroth II | 54 | 34 | 20 | |||
Total gastrectomy | Roux - en - Y | 32 | 19 | 13 | ||
Bone pain | 61 | 39 | 22 | NS | ||
BMI < 18.5 (kg/m2) | 21 | 10 | 11 | 0.07 | ||
Family history of osteoporosis | 10 | 6 | 4 | NS | ||
Type 2 diabetes | 13 | 8 | 5 | NS | ||
Anemia | 49 | 20 | 29 | < 0.01 | ||
sALP > 127 U/L | 18 | 12 | 6 | NS | ||
Past history of fracture | 24 | 14 | 10 | NS | ||
Vertebral deformity | 62 | 36 | 26 | NS |
Table 2 BMD of 133 patients with gastric adenocarcinoma patients according to sex (mean ± SD)
Male | Female | |||||
BMD | T score | Z score | BMD | T score | Z score | |
L1-4 | 0.979 ± 0.203 | -1.65 ± 1.63 | -0.55 ± 1.55 | 0.835 ± 0.243 | -2.31 ± 1.94 | -0.72 ± 1.49 |
Femur - neck | 0.837 ± 0.145 | -0.89 ± 1.13 | 0.44 ± 0.97 | 0.765 ± 0.170 | -1.11 ± 1.41 | 0.74 ± 1.14 |
Ward’s | 0.658 ± 0.151 | -1.72 ± 1.17 | 0.04 ± 1.01 | 0.588 ± 0.181 | -2.26 ± 1.40 | 0.13 ± 1.13 |
Trochanter | 0.768 ± 0.154 | -0.12 ± 1.40 | 0.65 ± 1.28 | 0.622 ± 0.139 | -1.20 ± 1.24 | -0.07 ± 0.96 |
Total hip | 0.911 ± 0.181 | -0.25 ± 1.45 | 0.79 ± 1.32 | 0.803 ± 0.174 | -1.12 ± 1.44 | 0.37 ± 1.13 |
Table 3 Univariate analysis for factors associated with osteoporosis
Variables | Patient number | P |
Age (yr) < 64/≥ 64 | 65/68 | 0.001 |
Male/female | 83/50 | 0.006 |
Duration after gastrectomy (yr) < 3/≥ 3 | 88/45 | 0.573 |
AGC/EGC | 75/58 | 0.858 |
TNM stage I/II/III/IV | 76/26/25/6 | 0.164 |
Total/partial gastrectomy | 31/102 | 0.528 |
Operation type Billroth I/II/Roux-en Y | 47/54/32 | 0.858 |
BMI < 18.5/≥ 18.5 kg/m2 | 21/112 | 0.001 |
Anemia; males, Hb < 13/≥ 13; females, Hb < 11/≥ 11 | 49/84 | 0.001 |
sALP < 127/≥ 127 U/L | 115/18 | 0.040 |
Previous fracture history +/- | 24/109 | 0.360 |
Family history of osteoporosis +/- | 8/125 | 0.482 |
Type 2 diabetes +/- | 13/111 | 0.369 |
Back pain +/- | 61/72 | 0.001 |
Vertebral deformity +/- | 62/71 | 0.001 |
Table 4 Multivariate analysis for factors associated with osteoporosis after stratification by sex
Variables | Odds ratio (95% CI) | P | |
Male | Anemia | 4.887 (1.404-17.011) | 0.011 |
Age ≥ 64 yr | 3.923 (1.202-12.805) | 0.018 | |
Female | Back pain | 10.272 (2.297-45.942) | 0.001 |
- Citation: Lim JS, Kim SB, Bang HY, Cheon GJ, Lee JI. High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy. World J Gastroenterol 2007; 13(48): 6492-6497
- URL: https://www.wjgnet.com/1007-9327/full/v13/i48/6492.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i48.6492