Expression of matrix metalloproteinase-1 and tumor necrosis factor-α in ulcerative colitis

Table 1 Expression of MMP-1 and TNF-α mRNA in samples from different areas of colon of UC patients (mean ± SD)

Samples	MMP-1 mRNA	TNF-α mRNA	P value
Ulcerated area	0.9797 ± 0.1433	0.8669 ± 0.0746	< 0.05ace
Inflamed area	0.6746 ± 0.0373	0.5227 ± 0.0435	< 0.05ac
Non-inflamed area	0.0071 ± 0.0025	0.0302 ± 0.0299	> 0.05
Normal controls	0.0062 ± 0.0029	0.0280 ± 0.0060

^aP < 0.05 vs non-inlamed area;

^cP < 0.05 vs normal controls;

^eP < 0.05 vs inflamed area.

Table 2 Expression of MMP-1 mRNA in samples from patients with different severity of UC (mean ± SD)

Samples	MMP-1 mRNA	TNF-α mRNA	P value
Ulcerated area	0.9797 ± 0.1433	0.8669 ± 0.0746	< 0.05ace
Inflamed area	0.6746 ± 0.0373	0.5227 ± 0.0435	< 0.05ac
Non-inflamed area	0.0071 ± 0.0025	0.0302 ± 0.0299	< 0.05
Normal controls	0.0062 ± 0.0029	0.0280 ± 0.0060

^aP < 0.05 vs moderate type;

^cP < 0.05 vs severe type;

^eP < 0.05 vs normal controls.

Table 3 Expression of MMP-1 and TNF-α proteins in samples from different areas of colon of UC patients (mean ± SD)

Samples	MMP-1	TNF-α	P value
Ulcerated area	0.0891 ± 0.0062	0.0903 ± 0.0054	< 0.05ace
Inflamed area	0.0791 ± 0.0047	0.0832 ± 0.0028	< 0.05ac
Non-inflamed area	0.0047 ± 0.0040	0.0036 ± 0.0013	> 0.05
Normal controls	0.0048 ± 0.0016	0.0029 ± 0.0021

^aP < 0.05 vs non-inlamed area;

^cP < 0.05 vs normal controls;

^eP < 0.05 vs inflamed area.

Table 4 Expression of MMP-1 and TNF-α protein in samples from UC patients with different severity of the disease

Samples	MMP-1	TNF-α	P value
Mild type	0.0749 ± 0.0032	0.0724 ± 0.0043	< 0.05ace
Moderate type	0.0812 ± 0.0030	0.0840 ± 0.0036	< 0.05ae
Severe type	0.0915 ± 0.0044	0.0932 ± 0.0019	< 0.05e
Normal controls	0.0048 ± 0.0016	0.0029 ± 0.0021

(mean ± SD)

^aP < 0.05 vs moderate type;

^cP < 0.05 vs severe type;

^eP < 0.05 vs normal controls.