Copyright
©2007 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 28, 2007; 13(4): 579-584
Published online Jan 28, 2007. doi: 10.3748/wjg.v13.i4.579
Published online Jan 28, 2007. doi: 10.3748/wjg.v13.i4.579
Table 1 Demographic and clinical characteristics of 58 patients, n (%)
Characteristics | |
Mean age, years, (range) | 36 (22–62) |
Sex | |
Male | 33 |
Female | 25 |
Race | |
Caucasian | 48 (100) |
ALT, IU/L (range) | 57 (9-263) |
HCV-RNA level, > 800.000 IU/mL | 23 (40) |
Mean level, IU/mL | 615.000 |
HCV genotype | |
1, 1a, 1b, 4 | 32 (55) |
2a, 2b, 3 | 24 (42) |
Not available | 2 (3) |
HCV genotype 1 and HCV-RNA > 800.000 IU/mL | 19 (33) |
Liver biopsy (available in 56 out of 58 patients) | |
No chronic hepatitis | 10 (17) |
Chronic hepatitis | 43 (74) |
Cirrhosis | 3 (5) |
Co-medication | |
Methadone | 4 (7) |
Codeine | 7 (12) |
Table 2 Sustained viralogical response by HCV genotype, gender and sex (wk 72), n (%)
All genotypes | |
< 800.000 IU/mL | 23/33 (70) |
≥ 800.000 IU/mL | 13/25 (52) |
Genotype 1 | |
< 800.000 IU/mL | 5/6 (83) |
≥ 800.000 IU/mL | 9/19 (47) |
Non-genotype 1 | |
< 800.000 IU/mL | 18/27 (67) |
≥ 800.000 IU/mL | 4/6 (67) |
Sex | |
Male | 16/33 (49) |
Female | 14/25 (56) |
Table 3 Frequency of laboratory abnormalities (n = 58)
Event | n |
Neutropenia | |
< 1500 | 21 |
< 1000 | 10 |
< 500 | 1 |
Anemia | |
< 10.5 g | 1 |
< 8.5 g | 0 |
Platelets | |
< 100.000 | 4 |
< 50.000 | 0 |
Table 4 Questionnaire (Int. Quality of Life Assessment SF-36). Listed are those answers presenting the majority of possible answers (%)
wk 0 | wk 12 | |
Personal feeling | Very good (76) | Good (63) |
Personal feeling compared to last week | Good (77) | Better (55) |
Impaired physical activity | Never (90) | Slightly (77) |
Impaired physical activity compared to last week | Never (88) | Slightly (73) |
Emotional problems | Never (93) | Never (48) |
Pain | None (90) | None (30) |
Pain last week | None (83) | None (54) |
Feeling depressed | Never (88) | Seldom (45) |
Feeling happy | Often (85) | Sometimes (50) |
Feeling tired | Seldom (77) | Sometimes (51) |
Impaired personal contact to relatives and friends due to disease | Never (88) | Seldom (71) |
“I’m feeling fit like others” | Mostly (94) | No (37) |
“I’m feeling healthy” | Mostly (78) | No (65) |
“I expect not to feel healthy” | Do not know (44) | No (32) |
- Citation: Witthoeft T, Fuchs M, Ludwig D. Recent IV-drug users with chronic hepatitis C can be efficiently treated with daily high dose induction therapy using consensus interferon: An open-label pilot study. World J Gastroenterol 2007; 13(4): 579-584
- URL: https://www.wjgnet.com/1007-9327/full/v13/i4/579.htm
- DOI: https://dx.doi.org/10.3748/wjg.v13.i4.579