A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity

doi:10.3748/wjg.v13.i39.5196

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 13, Issue 39

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (4031)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-6) series, Tables (1-4) series.

Item

Count

PDF

329

HTML

3190

Figures (1-6)

280

Tables (1-4)

232

Sum=4031

Oct 21, 2007 (publication date) through Jan 5, 2025

Times Cited of This Article

Times Cited (41)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

H Pylori

World J Gastroenterol. Oct 21, 2007; 13(39): 5196-5207
Published online Oct 21, 2007. doi: 10.3748/wjg.v13.i39.5196

Table 1 Toxicity studies with Swallow root pectic polysac-charide (n = 6) mean ± SD

Parameters	Control	SRPP treated
Total protein	348^a± 32.21	361.81^a± 28.10
SGOT (U/mg protein)	18.34^a± 1.55	16.22^a± 1.34
SGPT (U/mg protein)	21.31^a± 2.70	23.21^a± 2.29
ALP (U/mg protein)	35.52^a± 3.879	33.62^a± 2.95
TBARS (n moles/mg protein)	0.166^a± 0.08	0.186^a± 0.11

SGPT: Serum glutamate pyruvate transaminase; SGOT: Serum glutamate oxaloacetate transaminase; ALP: Alkaline phosphatase; TBARS: Thiobarbituric acid reactive substances.

^aP < 0.05 between control and SRPP treated groups.

Table 2 Gastric mucin and H⁺, K⁺-ATPase levels in healthy, ulcerated and protected rats (n = 6) mean ± SD

Group, n = 6	Mucin content (mg/g)	H⁺, K⁺-ATPase (μmoles Pi released/mg/h)
Healthy	45.04^d± 4.128	0.807^d± 0.072
Swim stress induced ulcer model
Swim stress induced	17.78^a± 2.557	2.209^a± 0.152
SRPP 100 mg/kg b.w.	27.13^b± 4.082	1.771^b± 0.081
SRPP 200 mg/kg b.w.	35.35^c± 3.221	1.601^b± 0.091
Ranitidine 50 mg/kg b.w.	31.42^b,c± 2.327	1.621^b± 0.092
Ethanol stress induced ulcer model
Ethanol stress induced	16.32^a± 3.821	2.621^a± 0.211
SRPP 100 mg/kg b.w.	32.13^b± 3.457	2.123^b± 0.241
SRPP 200 mg/kg b.w.	39.53^b,c± 3.082	1.512^c± 0.121
Ranitidine 50 mg/kg b.w.	37.13^b± 1.507	1.485^c± 0.124

Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups. Range was provided by Duncan multiple test at P < 0.05. a: Less significant; b: Moderately significant; c: Very significant and d: Most significant.

Table 3 Antioxidant/antioxidant enzymes and TBARS levels in swim stress induced ulcer model (n = 6) mean ± SD

Parameters	Protein (mg/g)	SOD (U/mg)	Catalase (U/mg)	Glutathione Peroxidase (ηmoles/g)	GSH (nmoles/mg)	TBARS ηmoles
Stomach
Healthy	2.23^c± 0.21	9.86^a± 1.1	829.2^c± 41.6	0.21^a± 0.009	224^c± 10.0	0.31^a± 0.01
Ulcerated	1.95^a± 0.13	19.10^c± 1.8	462.4^a± 30.2	0.49^d± 0.01	121^a± 18.9	1.12^c± 0.20
SRPP 100 mg/kg	1.90^a± 0.09	16.32^b,c± 2.1	488.1^a,b± 32.8	0.34^b± 0.02	174^b± 22.1	0.94^c± 0.10
SRPP 200 mg/kg	2.10^b± 0.19	13.06^b± 2.6	679.6^b± 9.9	0.22^a± 0.01	208^c± 16.5	0.55^a,b± 0.00
Ranitidine	2.16^b± 0.22	15.22^b± 1.2	505.5^a,b± 35.5	0.39^c± 0.01	136^a± 12.1	0.92^b± 0.10
Serum
Healthy	6.62^a± 0.51	112.3^a± 28	44.20^c± 4.9	0.221^a± 0.004	23.6^c± 3.0	0.165^a± 0.01
Ulcerated	6.84^a± 0.53	264.6^d± 32	22.90^a± 3.1	0.286^c± 0.02	11.1^a± 1.8	0.326^d± 0.02
SRPP 100 mg/kg	6.35^a± 0.59	201.1^c± 36	28.63^b± 2.3	0.298^d± 0.03	16.5^b± 2.1	0.261^c± 0.03
SRPP 200 mg/kg	6.95^a± 0.48	168.2^b± 21	40.12^c± 3.8	0.268^b± 0.03	19.8^b,c±12.9	0.162^a± 0.01
Ranitidine	6.35^a± 0.63	196.3^b,c±23	30.82^b± 2.9	0.226^a± 0.02	12.8^a± 2.6	0.186^b± 0.01
Liver
Healthy	24.2^c± 0.31	261.5^b± 41	28.42^d± 3.1	0.32^a± 0.02	414^c± 51	0.98^a± 0.13
Ulcerated	21.9^a± 0.23	142.4^a± 18	22.18^b,c± 2.6	0.58^c± 0.05	221^a± 26	2.41^d± 0.23
SRPP 100 mg/kg	23.1^b± 0.28	164.2^a± 13	19.63^b,c± 2.4	0.36^a,b± 0.03	315^b± 36	1.84^c± 0.16
SRPP 200 mg/kg	23.9^b± 0.28	361.5^d± 39	15.54^a± 2.1	0.28^a± 0.02	214^a± 24	1.26^b± 0.11
Ranitidine	23.6^b± 0.26	314.4^c,d± 36	17.34^a± 1.9	0.32^a± 0.02	254^a± 28	1.41^b± 0.12

SOD: Superoxide dismutase; GSH: Glutathione; TBARS: Thiobarbituric acid reactive substances. Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups.

Table 4 Antioxidant/antioxidant enzymes and TBARS levels in ethanol induced ulcer model (n = 6) mean ± SD

Parameters	Protein (mg/g)	SOD (U/mg)	Catalase (U/mg)	Glutathione Peroxidase (ηmoles/g)	GSH (U/mg)	TBARS ηmoles
Stomach
Healthy	2.23^a± 0.21	09.86^a± 1.1	829.2^c± 41.6	0.21^a± 0.009	224^d± 23.2	0.31^a± 0.1
Ulcerated	2.32^a± 0.09	17.86^c± 2.4	201.5^a± 18.9	0.30^c± 0.01	102^a± 12.6	1.26^d± 0.3
SRPP 100 mg/kg	2.16^a± 0.16	16.21^c± 1.0	193.3^a± 62.5	0.26^b± 0.01	162^b± 15.5	0.92^c± 0.1
SRPP 200 mg/kg	2.41^a± 0.20	11.09^b± 1.0	540.5^b± 40.2	0.33^c± 0.02	196^c± 16.4	0.54^b± 0.1
Ranitidine	2.42^a± 0.19	12.42^b±1.4	468.6^c± 31.6	0.22^a± 0.03	152^b± 16.3	0.96^c± 0.2
Serum
Healthy	6.62^a± 0.51	112.3^a± 28	44.20^c± 4.9	0.221^a± 0.04	23.6^d± 3.0	0.165^a± 0.01
Ulcerated	6.52^a± 0.69	282.3^d± 26	28.36^a± 3.2	0.315^c± 0.03	9.6^a± 1.2	0.465^d± 0.03
SRPP 100 mg/kg	6.35^a± 0.70	228.4^c± 32	34.25^a,b± 3.3	0.286^b± 0.03	18.6^c± 2.2	0.321^c± 0.04
SRPP 200 mg/kg	6.24^a± 0.56	172.3^b± 2	39.60^b± 4.51	0.243^b± 0.02	18.2^c± 1.9	0.181^a± 0.02
Ranitidine	6.32^a± 0.69	210.7^c±28	34.12^ab± 4.6	0.252^b± 0.03	14.6^b± 1.6	0.214^a,b± 0.02
Liver
Healthy	24.2^a± 0.31	261.5^b± 1.1	28.42^c± 3.1	0.32^b± 0.02	414^c± 51	0.98^a± 0.13
Ulcerated	24.3^a± 0.31	118.1^a± 16	19.64^b± 2.2	0.48^b,c± 0.03	392^b,c± 41	2.98^d± 0.31
SRPP 100 mg/kg	23.5^a± 0.21	121.8^a± 15	18.32^b± 1.6	0.39^b± 0.03	268^b± 25	2.15^c± 0.22
SRPP 200 mg/kg	26.4^a± 0.41	325.4^c± 34	13.17^a± 1.6	0.29^a± 0.02	241^a,b± 28	1.65^b± 0.14
Ranitidine	26.8^a± 0.29	254.5^b± 26	14.24^a± 1.8	0.31^a± 0.03	211^a± 28	1.61^b± 0.16

Range was provided by Duncan multiple test at P < 0.05. a: Less significant; b: Moderately significant; c: Very significant and d: most significant. Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups.

Citation: Srikanta B, Siddaraju M, Dharmesh S. A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity. World J Gastroenterol 2007; 13(39): 5196-5207
URL: https://www.wjgnet.com/1007-9327/full/v13/i39/5196.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i39.5196