A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease

Table 1 Thirty-nine genes associated (r > 0.50) with the degree of liver fibrosis (MFI value)

Accession No.	Gene Name	Description	CC1
NM_002646	PIK3C2B2	Phosphoinositide-3-kinase, class 2, beta polypeptide	0.60
NM_152270	NM_1522702	Hypothetical protein FLJ34922 (FLJ34922)	0.59
NP113470	NP113470	Unknown	0.58
AK024488	AK024488	FLJ00087 protein	0.57
AB064167	AB064167	IGL mRNA for immunoglobulin lambda light chain VLJ region	0.57
BC015833	BC015833	cDNA clone MGC:27152 IMAGE:4691630	0.57
A_23_P32661	A_23_P32661	Unknown	0.57
M35730	M35730	MHC class II DQ3.1ER (DR4)	0.56
NP077661	NP077661	Unknown	0.56
D29642	D29642	KIAA0053	0.56
NM_001778	CD48	CD48 antigen (B-cell membrane protein)	0.56
NM_006144	GZMA	Granzyme A (granzyme 1, cytotoxic) T-lymphocyte-associated serine esterase 3)	0.56
NM_002125	HLA-DRB5	MHC class II, DR beta 5	0.55
NM_001803	CDW52	CDW52 antigen (CAMPATH-1 antigen)	0.55
NP649772	NP649772	Unknown	0.54
THC1889877	THC1889877	Unknown	0.54
AX721203	AX721203	Sequence 163 from Patent WO0220754	0.54
BC036926	BC0369262	cDNA clone MGC:46491 IMAGE:5225843	0.54
M13975	M13975	Protein kinase C beta-II type (PRKCB1)	0.53
AF035024	AF035024	MCE11H myosin-reactive immunoglobulin heavy chain variable region	0.53
NM_033503	BMF	Bcl2 modifying factor (BMF), mRNA	0.53
A_23_P124264	A_23_P124264	Unknown	0.53
U96396	U96396	Anti-streptococcal/anti-myosin immunoglobulin kappa light chain variable region	0.53
A_23_P435390	A_23_P435390	Unknown	0.53
A_23_P9854	A_23_P9854	Unknown	0.52
AF490771	AF490771	MHC class II antigen (HLA-DRB1) mRNA, HLA-DRB1*1401 allele	0.52
NM_002121	HLA-DPB1	MHC class II, DP beta 1	0.52
L03178	L03178	Cell-type T-cell immunoglobulin gamma chain, V region (IGHV@)	0.52
NM_170744	UNC5B	Unc-5 homolog B (C. elegans)	0.51
S65186	S651862	EMT=T-cell-specific tyrosine kinase	0.51
NM_022555	HLA-DRB3	MHC class II, DR beta 3	0.51
NM_001175	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.51
NM_002118	HLA-DMB	MHC class II, DM beta	0.51
NM_002838	PTPRC	Protein tyrosine phosphatase, receptor type, C	0.51
L34102	L34102	MHC class II HLA-DQB1*0502	0.51
AB020689	AB020689	KIAA0882 protein	0.51
NM_002341	LTB	Lymphotoxin beta (TNF superfamily, member 3)	0.50
AJ297586	AJ297586	MHC class II antigen (HLA-DRB1 gene), DRB1*0402 allele	0.50
NM_033554	HLA-DPA1	MHC class II, DP alpha 1	0.50

¹For each clone, the correlation coefficient (CC) between the gene expression level and the morphological fibrosis index (MFI) was determined;

²These 4 clones were used to calculate the genetic fibrosis index (GFI).