Novel mutations and sequence variants in exons 3-9 of human T Cell Factor-4 gene in sporadic rectal cancer patients stratified by microsatellite instability

Table 1 Sequence analysis of hTCF-4 exons 3-9 in sporadic rectal cancer patients with MSI-H and controls

				Frequency
Exon	Nucleotidechange	Amino acidchange	Mutationtype	Patients(n = 10)	Controls(n = 10)
4	4-position
	continuous
	alteration1	Q131T	Missense	5	0
4	395delC	S132I	Frameshift	4	0
4	450 G > C	Q150H	Missense	1	0
8	868 G > A	V290M	Missense	2	0

¹4-position continuous alteration refers to the mutation (391insA, 392 G > A, 393 A > G and 395delC).

Table 2 Clinical details of 10 MSI-H rectal cancer patients

Case	Age	Sex	Size	Pathology	TNM	CEA
No.	(yr)		(mm)		stage	(ng/mL)
1	54	F	20	Mucinous	I	1.55
2	28	F	50	Mucinous	IV	310.5
3	68	F	60	Mucinous	II	3.47
4	49	F	40	Mucinous	II	1.6
5	51	M	40	Unmucinous	II	10.11
6	36	M	100	Mucinous	II	6.37
7	71	F	40	Unmucinous	I	3.53
8	47	M	40	Unmucinous	III	4.96
9	54	M	80	Unmucinous	II	4.3
10	54	M	80	Unmucinous	III	5.8