Correlation of intestinal disaccharidase activities with the C/T-13910 variant and age

Table 1 Distribution of disaccharidase activities among Finnish adult population in relation to the C/T_-13910 genotypes

Disaccharidase	n	Genotype			Total 222	P
		C/C-13910	C/T-13910	T/T-13910
		56	83	83
Lactase		6.86 ± 0.35 (3-16)	37.8 ± 1.4 (21-99)	57.6 ± 2.4 (20-127)	37.4 ± 1.7 (3-127)	< 0.00001
Sucrase		77.2 ± 3.7 (40-172)	87.2 ± 3.8 (35-240)	83.2 ± 4,3 (24-260)	83.2 ± 2.4 (24-260)	0.14
Maltase		287.7 ± 13.2 (159-599)	342.0 ± 13.5 (161-868)	305.5 ± 14.5 (140-887)	314.6 ± 8.2 (140-887)	0.005
L/S ratio		0.09 ± 0.005 (0.03-0.2)	0.46 ± 0.02 (0.2-1.6)	0.73 ± 0.02 (0.25-1.35)	0.47 ± 0.02 (0.03-1.6)	< 0.00001

Disaccharidase activities are expressed as U/g protein, mean ± SE (range); P value based on Kruskal-Wallis test; L/S = lactase/sucrase ratio.

Table 2 Distribution of disaccharidase activities among Finnish population in different age groups

Disaccharidase	n	Age groups (yr)			Total 222	P
		18-39	40-59	60-83
		84	94	44
Lactase		35.6 ± 2.4	39.3 ± 3	37 ± 3.5	37.4 ± 1.7	0.84
Sucrase		77.3 ± 2.8	86.6 ± 4.5	87.4 ± 4.5	83.2 ± 2.4	0.18
Maltase		298 ± 11	326 ± 16	324 ± 13	315 ± 8	0.24
L/S ratio		0.48 ± 0.03	0.48 ± 0.03	0.43 ± 0.04	0.47 ± 0.02	0.70

Disaccharidase activities are expressed as U/g protein, mean ± SE; P value based on Kruskal-Wallis test.

Table 3 Distribution of disaccharidase activities in different lactase variant genotypes for various age groups of finnish population

Genotype	Disaccharidase	Age groups (yr)			Total	P
		18-39	40-59	60-83
C/C-13910	n	20	25	11	56
	Lactase	7.05 ± 0.49 (6.17-7.55)	6.84 ± 0.6 (5.6-8.08)	6.54 ± 0.72 (4.94-8.15)	6.86 ± 0.35 (6.17-7.55)	0.74
	Sucrase	76.6 ± 5.9 (64.2-88.91)	77.4 ± 6.24 (64.5-90.3)	78.0 ± 7.72 (60.8-95.2)	77.2 ± 3.74 (69.7-84.7)	0.95
	Maltase	288.2 ± 23.7 (239-338)	288 ± 20.8 (245-331)	286.2 ± 23.6 (234-339)	287.7 ± 13.2 (261-314)	0.96
C/T-13910	n	32	34	17	83
	Lactase	34.7 ± 1.7 (31-38)	39.7 ± 2.9 (34-46)	39.8 ± 2.2 (35-45)	37.8 ± 1.4 (35-41)	0.18
	Sucrase	80.5 ± 4.3 (72-89)	87.2 ± 7.3 (72-102)	99.9 ± 8.1 (83-117)	87.2 ± 3.8 (80-95)	0.11
	Maltase	321 ± 16 (287-354)	344 ± 27 (290-399)	377 ± 21 (333-421)	342 ± 13 (315-369)	0.08
T/T-13910	n	32	35	16	83
	Lactase	54.2 ± 3.3 (47.5-60.9)	62.0 ± 4.2 (53.5-70.5)	54.9 ± 5.2 (43,8-66)	57.6 ± 2.4 (52.8-62.4)	0.42
	Sucrase	74.5 ± 4.6 (65.1-83,8)	92.5 ± 8.8 (67.7-93.4)	80.6 ± 6.03 (67.7-93.4)	83.2 ± 4.3 (74.6-91.9)	0.49
	Maltase	281 ± 17 (246-315)	334 ± 29 (274-394)	293 ± 18 (254-331)	305 ± 15 (277-334)	0.64

Disaccharidase activities are expressed as U/g protein, mean ± SE (95% confidence interval); P value based on Kruskal-Wallis test.