Difference in gene expression of macrophage between normal spleen and portal hypertensive spleen idendified by cDNA microarray

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Jun 28, 2007 (publication date) through Jan 13, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2007; 13(24): 3369-3373
Published online Jun 28, 2007. doi: 10.3748/wjg.v13.i24.3369

Table 1 Differentially expressed genes up-regulated in macrophages of portal hypertensive spleen

GenBank No.	Gene name and description	Average ratio
AF189009	UBQLN2, ubiquilin 2	2.117
BX537509	NET1, neuroepithelial cell transforming gene 1	2.270
NM_004830	CRSP3, cofactor required for Sp1 transcriptional activation	2.334
AF025771	ZNF189, zinc finger protein 189	2.453
AK090727	Homo sapiens cDNA FLJ33408 fis, clone BRACE2010550	2.511
BX537955	TRIM37, tripartite motif-containing 37	2.553
NM_006716	ASK, activator of S phase kinase	2.620
NM_181523	PIK3R1, phosphoinositide-3-kinase, regulatory subunit 1	2.755
XM_376537	Homo sapiens BCL2-associated transcription factor 1 (BCLAF1), mRNA	2.993
NM_004416	DTX1, deltex homolog 1 (Drosophila)	3.553

Table 2 Differentially expressed genes down-regulated in macrophages of portal hypertensive spleen

GenBank No.	Gene name and description	Average ratio
BC068441	IL1RN, interleukin 1 receptor antagonist	0.179
NM_014909	KIAA1036	0.268
BU732296	Homo sapiens cDNA clone UI-E-CI1-afo-e-04-0-UI 3', mRNA sequence	0.275
AK092248	Homo sapiens cDNA FLJ34929 fis, clone NT2RP7004728	0.293
NM_006254	PRKCD, protein kinase C, delta	0.298
BX648172	OAZ2, ornithine decarboxylase antizyme 2	0.302
BM542499	Homo sapiens cDNA clone IMAGE:5521023 5', mRNA sequence	0.311
BF240734	Homo sapiens cDNA clone IMAGE:4091885 5', mRNA sequence	0.324
NM_003902	FUBP1, far upstream element (FUSE) binding protein 1	0.338
BM993772	Homo sapiens cDNA clone IMAGE:5869020 3', mRNA sequence	0.344
NM_005373	MPL, myeloproliferative leukemia virus oncogene	0.359
BX647757	SCML1, sex comb on midleg-like 1 (Drosophila)	0.370
NM_005781	ACK1, activated Cdc42-associated kinase 1	0.381
AL832249	Homo sapiens mRNA; cDNA DKFZp686P1077	0.390
AK092130	LOC285378, hypothetical protein LOC285378	0.406
AF466367	Homo sapiens clone KU011197 unknown mRNA	0.434
NM_001067	TOP2A, topoisomerase (DNA) II alpha	0.437
AF051151	TLR5, toll-like receptor 5	0.452

Citation: Yan F, Wang XM. Difference in gene expression of macrophage between normal spleen and portal hypertensive spleen idendified by cDNA microarray. World J Gastroenterol 2007; 13(24): 3369-3373
URL: https://www.wjgnet.com/1007-9327/full/v13/i24/3369.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i24.3369