Establishing models of portal vein occlusion and evaluating value of multi-slice CT in hepatic VX2 tumor in rabbits

Table 1 Results of examination of corpses in 3-wk group and positive control group (n = 10)

Group	Maximaldiameter (cm)	Metastasis inliver (n/%)	Metastasis inlung (n/%)	Closemetastasis (n)
3-wk	2.55 ± 0.46b	1/10b	4/10a	7
Positive control	3.59 ± 0.37	10/10	9/10	9

^aP < 0.05,

^bP < 0.001, vs positive control group.

Table 2 The expression intensity of VEGF in groups A, B, C and D (n = 10)

Group	VEGF	t	P
Group A	0.10 ± 0.06	5.07	0.00
Group C	0.28 ± 0.09
Group B	0.66 ± 0.21	6.38	0.00
Group D	1.48 ± 0.32

Table 3 The success rate of MSCTA, DSA and vascular perfusion of the hepatic artery and portal vein (n/%)

	MSCTA	DSA	Vascular perfusion
Hepatic artery	100% (40/40)	85% (17/20)1	97.3% (36/37)
Portal vein	100% (40/40)	95% (19/20)	97.4% (38/39)

¹ The success rate of MSCTA and DSA of hepatic artery, P < 0.05.

Table 4 Comparisons of vascular-imaging displaying rate of MSCTA, DSA and vascular perfusion of hepatic artery [%(n/n)]

Grade	MSCTA(n = 40)	DSA(n = 17)	Vascular perfusion(n = 33)
GradeI	100 (40/40)	100 (17/17)	97.0 (32/33)
GradeII	70 (28/40)	100 (17/17)	90.9 (30/33)
≥ GradeIII	40 (16/40)	88.24 (15/17)	75.77 (25/33)

Table 5 Comparisons of vascular-imaging displaying rate of MSCTA, DSA and vascular perfusion of portal vein [%(n/n)]

Grade	MSCTA(n = 40)	DSA(n = 19)	Vascular perfusion(n = 38)
GradeI	100 (40/40)	100 (19/19)	100 (38/38)
GradeII	100 (40/40)	94.7 (18/19)	100 (38/38)
≥ GradeIII	100 (40/40)	89.5 (17/19)	100 (38/38)

Table 6 Comparison of parameters of multi-slice CT (mean ± SD, n = 10)

CT-perfused parameter	Group A	Group B	Group C	Group D
Blood flow in per 100 g hepatic tissue (mL/min)	1.40 ± 0.70	48.76 ± 7.31	133.21 ± 14.42b	296.53 ± 39.62d
Blood volume in per 100 g hepatic tissue (mL)	0.33 ± 0.17	3.33 ± 0.53	28.77 ± 3.32b	30.64 ± 3.32d
Mean transit time (s)	4.33 ± 1.41	14.7 ± 1.66	11.67 ± 0.58b	6.79 ± 0.85d
Permeability of vascular surface in per 100 g hepatic tissue (mL/min)	0.15 ± 0.18	11.71 ± 2.33	22.10 ± 4.39b	36.16 ± 5.91d
Hepatic arterial infusion	0.99 ± 0.03	0.99 ± 0.02	0.25 ± 0.06b	0.63 ± 0.01d

^bP < 0.01 vs immediate group;

^dP < 0.01 vs 3-wk group.

Table 7 Coefficient correlation of MSCT perfusion parameters and VEGF (r)

Parameters	BV	MTT	PS	HAF	VEGF
BF	0.905b	-0.132	0.967b	-0.494	0.842b
BV		-0.057	0.889b	-0.768b	0.579b
MTT			0.044	-0.157	-0.066
PS				-0.557b	0.811b
HAF					-0.027

^bP < 0.01.