Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021

doi:10.3748/wjg.v13.i21.2992

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Jun 7, 2007 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2007; 13(21): 2992-2998
Published online Jun 7, 2007. doi: 10.3748/wjg.v13.i21.2992

Table 1 Scoring standard of pathological changes in rat pancreatic tissues with SAP

Pathological	Pathological	Scores
grading	change
Edema	Inter-lobule local edema, widened pleura	1
	Inter-lobule diffuse edema, widened intra-lobule
	clearance	2

	Increased intra-lobule clearance, alveolus swollen,
	and separated	3

Inflammatory	White cells < 20/visual field under high-power
	microscope	1
	White cells 20-50/visual field under
	high-power microscope	2
	White cells > 30/visual field under high-power
	microscope, or micro-abscess occurs	3

Hemorrhage	Parenchymal hemorrhage < 20%	1
	Parenchymal hemorrhage 20%-50%	2
	Parenchymal hemorrhage > 50%	3

Necrosis	Necrosis area < 20%	1
	Necrosis area 20%-50%	2
	Necrosis area > 50%	3

Table 2 Serum amylase level at different time points in each group after operation (n = 10, mean ± SD, U/L)

Groups	Time phase points (h)
Groups	1	2	3	6	12	24
NC	1835.6	1491.5	1530.4	1400.2	2153.2	1337
NC	± 613.2	± 507.0	± 247.0	± 447.5	± 236.3	± 243.7
SAP	2560.5	2810.5	4799.3	4919.7	3486.3	2283
SAP	± 121.5^a	± 147.2^a	± 107.0^a	± 139.6^a	± 181.8^a	± 127.0^a
BN	2214.5	3331.7	4185	3784.7	3454	1360.4
BN	± 109.1^a	± 196.4^a	± 147.8^a^b	± 124.1^a^b	± 264.1^a	± 161.4^b

^aP < 0.05 vs NC group;

^bP < 0.05 vs SAP group.

Table 3 Scores of pancreatic tissues at different time points in each group after operation (n = 10, mean ± SD)

Groups	Time phase points (h)
Groups	1	2	3	6	12	24
NC	0.12 ± 0.05	0.11 ± 0.06	0.12 ± 0.05	0.13 ± 0.04	0.12 ± 0.06	0.13 ± 0.05
SAP	4.82 ± 0.35^a	7.65 ± 0.40^a	8.85 ± 0.39^a	9.15 ± 0.55^a	10.10 ± 0.65^a	11.75 ± 0.25^a
BN	5.55 ± 0.30^a	6.65 ± 0.42^a	5.95 ± 0.19^a^b	5.55 ± 0.36^a^b	6.72 ± 0.30^a^b	9.95 ± 0.58^a

^aP < 0.05 vs NC group;

^bP < 0.05 vs SAP group.

Table 4 Absorbance values of PAF-R mRNA in pancreatic tissues at various time points in each group after operation (n = 10, mean ± SD)

Groups	Time phase points (h)
	1	2	3	6	12	24
NC	0.46	0.48	0.47	0.47	0.46	0.43
	± 0.10	± 0.10	± 0.10	± 0.09	± 0.10	± 0.09
SAP	0.49	0.54	0.71	0.38	0.25	0.20
	± 0.09	± 0.14	± 0.14^a	± 0.08^a	± 0.07^a	± 0.06^a
BN	0.49	0.51	0.69	0.59	0.29	0.20
	± 0.05	± 0.07	± 0.13^a	± 0.04^a	± 0.05^a	± 0.04^a

^aP < 0.05 vs NC group.

Table 5 Absorbance values of PAF-R protein in pancreatic tissues at various time points in each group after operation (n = 10, mean ± SD)

Groups	Time phase points (h)
	1	2	3	6	12	24
NC	0.44 ± 0.02	0.48 ± 0.02	0.48 ± 0.03	0.49 ± 0.09	0.52 ± 0.08	0.49 ± 0.10
SAP	0.53 ± 0.03	0.90 ± 0.02^a	1.69 ± 0.06^a	1.12 ± 0.10^a	1.04 ± 0.14^a	0.97 ± 0.16^a
BN	0.43 ± 0.06	0.80 ± 0.05^a	1.58 ± 0.02^a	0.98 ± 0.03^a	0.87 ± 0.02^a	0.90 ± 0.05^a

^aP < 0.05 vs NC group.

Citation: Xia SH, Hu CX, Zhao ZL, Xia GD, Di Y. Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. World J Gastroenterol 2007; 13(21): 2992-2998
URL: https://www.wjgnet.com/1007-9327/full/v13/i21/2992.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i21.2992