Prognostic value of DNA alterations on chromosome 17p13.2 for intrahepatic cholangiocarcinoma

Table 1 Clinocopathological parameters and DNA amplification of the target fragment (518 bp) on chromosome 17p13.2 in ICC patients

Parameters	DNA amplification		P	OR (95% CI)
	+	-
	n (%)	n (%)
Age (yr)			0.771
≤ 50	6 (37.5)	10 (62.5)		1.00 (referent)
> 50	12 (33.3)	24 (66.7)		0.83 (0.24-2.84)
Gender			0.69
Male	14 (33.3)	28 (66.7)		1.00 (referent)
Female	4 (40.0)	6 (60.0)		1.33 (0.32-5.51)
Histological type			0.61
Well-differentiated	7 (29.2)	17 (70.8)		1.00 (referent)
Moderately differentiated	7 (50.0)	7 (50.0)		2.43 (0.51-12.04)
Poorly differentiated	5 (45.5)	6 (54.5)		2.02 (0.37-11.45)
Tumor size (cm)			0.843
≤ 7	3 (20.0)	12 (80.0)		1.00 (referent)
> 7	3 (23.1)	10 (76.9)		1.20 (0.20-7.31)
Metastasis			0.368
Positive	14 (40.0)	21 (60.0)		1.83 (0.41-8.58)
Negative	4 (26.7)	11 (73.3)		1.00 (referent)
Lymph node metastasis			0.197
Positive	8 (53.3)	7 (46.7)		2.29 (0.54-9.88)
Negative	10 (33.3)	20 (66.7)		1.00 (referent)

Table 2 Clinocopathological parameters and allelic loss of the target fragment (518 bp) on chromosome 17p13.2 in ICC patients

Parameters	Allelic loss		P	OR (95% CI)
	+	-
	n (%)	n (%)
Age (yr)			0.456
≤ 50	3 (18.8)	13 (81.3)		1.00 (referent)
> 50	4 (11.1)	32 (88.9)		0.54 (0.11-2.76)
Gender			0.721
Male	6 (14.3)	36 (85.7)		1.00 (referent)
Female	1 (10.0)	9 (90.0)		0.67 (0.07-6.26)
Histological type			0.726
Well-differentiated	6 (25.0)	18 (75.0)		1.00 (referent)
Moderately differentiated	6 (42.85)	8 (57.15)		2.25 (0.45-11.62)
Poorly differentiated	3 (27.27)	8 (72.73)		1.13 (0.17-7.25)
Tumor size (cm)			0.63
≤ 7	2 (13.3)	13 (86.7)		1.00 (referent)
> 7	1 (7.7)	12 (92.3)		0.54 (0.04-6.77)
Metastasis			0.447
Positive	5 (14.3)	30 (85.7)		2.33 (0.22-57.93)
Negative	1 (6.7)	14 (93.3)		1.00 (referent)
Lymph node metastasis			0.737
Positive	2 (13.3)	13 (86.7)		1.38 (0.14-12.27)
Negative	3 (10.0)	27 (90.0)		1.00 (referent)