The interferon inducing pathways and the hepatitis C virus

Table 1 Sequence of the NS3/4A -mediated cleavages in HCV polyprotein from different genotypes

Name	Genotype (GI)	NS3/4A	NS4A/4B	NS4B/5A	NS5A/5B	Reference
H77	1a (GI: 2316097 )	MSADLEVVT STWVLVGG	QEFDEMEEC SQHLPYIE	ISSECTTPC SGSWLRDI	ADTEDVVCC SSYSWTGA	Kolykhalov et al, 1997
HCV-N	1b (GI: 23957856)	MSADLEVVT STWVLVGG	REFDEMEEC ASHLPYIE	INEDCSTPC SGSWLRDV	EAGESVVCC SMSYTWTG	Beard et al, 1999
JFH1	2a (GI: 13122261)	MQADLEVMT STWVLAGG	EAFDEMEEC ASRAALIE	ITEDCPIPC SGSWLRDV	EEDDTTVCC SMSYSWTG	Kato et al, 2001
NZL1	3a (GI: 514395)	MSADLEVTT STWVLLGG	QQYDEMEEC SQAAPYIE	INEDYPSPC SDDWLRTI	SEEQSVVCC SMSYSWTG	Sakamoto et al, 1994
ED43	4a (GI: 2252489)	MSADLEVVT STWVLVGG	QQFDEMEEC SKHLPLVE	INEDCSTPC STPCAESW	SGSEDVVCC SMSYSWTG	Chamberlain et al, 1997
SA13	5a (GI: 3660725)	MSADLEVIT STWVLVGG	QQFDEMEEC SASLPYMD	IGEDYSTPC DGTWLRAI	SDEDSVVCC SMSYSWTG	Bukh et al, 1998
6a33	6a (GI: 57791993)	MSADLEVIT STWVLVGG	QQFDEMEEC SRHIPYLAE	VNEDTATPC ATSWLRDV	SDQDDVVCC SMSYSWTG	Zhou et al, 2004

The sequence of the junction between the non structural proteins NS3 and NS4A (NS3/4A) , NS4A and NS4B (NS4A/4B), NS4B and NS5A (NS4B/5A) and NS5A and NS5B ( NS5A/5B) is given for 6 different HCV genotypes. The gene accession number (GI) for each is given in the Genotype column. For each sequence, the space indicates the NS3/4A-cleavage site. The consensus cleavage site is given in the text.