Hepatitis C virus proteins

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May 7, 2007 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 7, 2007; 13(17): 2406-2415
Published online May 7, 2007. doi: 10.3748/wjg.v13.i17.2406

Table 1 Viral proteins and their functions in HCV life cycle

Protein	Molecular Mass¹	Function
Core	21 kDa	RNA binding; nucleocapsid
E1	31-35 kDa	Envelope glycoprotein; associate with E2
E2	70 kDa	Envelope glycoprotein; receptor binding; associate with E1
p7	7 kDa	Ion channel
NS2	21 kDa	Component of NS2-3 proteinase
NS3	69 kDa	N-terminal proteinase domain;
		C-terminal NTPase/helicase domain
NS4A	6 kDa	NS3-4A proteinase cofactor
NS4B	27 kDa	Induces membrane alterations
NS5A	56-58 kDa	Phosphoprotein
NS5B	68 kDa	RNA-dependent RNA polymerase

Estimated by SDS-PAGE.

Citation: Dubuisson J. Hepatitis C virus proteins. World J Gastroenterol 2007; 13(17): 2406-2415
URL: https://www.wjgnet.com/1007-9327/full/v13/i17/2406.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i17.2406