Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia

doi:10.3748/wjg.v13.i16.2333

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Apr 28, 2007 (publication date) through May 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2007; 13(16): 2333-2338
Published online Apr 28, 2007. doi: 10.3748/wjg.v13.i16.2333

Table 1 Monoclonal antibodies used in this study

Clone	Specificity	Isotype	Label	Source
SK7	CD3	IgG1	PE	Becton- Dickinson, Le Pont de Claix, France
SK7/SK1/ 2D1/SK3	CD3/CD8/ CD45/CD4	IgG1/IgG1/ IgG1/IgG1	FITC/PE/ Per CP/APC	Becton- Dickinson, Le Pont de Claix, France
Ber-ACT8	CD103 (αE subunit of the αEβ7 integrin)	IgG1	FITC	Becton- Dickinson, Le Pont de Claix, France
CD28.2	CD28	IgG1	FITC	Becton- Dickinson, Le Pont de Claix, France
G44-26,	CD44	IgG2b	FITC	Becton- Dickinson, Le Pont de Claix, France
11F2	TCR-γδ	IgG1	FITC	Becton- Dickinson, Le Pont de Claix, France
L78	CD69	IgG1	FITC	Becton- Dickinson, Le Pont de Claix, France
CR3/43	HLA-DR	IgG1	FITC	Dako, Glostrup, Denmark
UB2	CD95/Fas	IgG1	FITC	Immunotech, Marseille, France

Table 2 Immunophenotype of duodenal intraepithelial lymphocytes in H pylori negative (Hp-) and positive (Hp+) dyspeptic patients and healthy control adults

IEL	Hp- dyspepticpatients (n = 20)Median %(range %)	Hp+ dyspepticpatients (n = 6)Median %(range %)	Healthy controladults (n = 12)Median %(range %)	P
CD3+	93 (80-98)	94.5 (89-99)	96 (84-99)	^a^c^eP > 0.5

CD3+ CD4+	8 (3-34)	8 (3-15)	10 (2-22)	^a^c^eP > 0.5

CD3+ CD8+	78 (58-96)	86 (75-87)	77 (53-87)	^a^cP > 0.5
				^bP < 0.01
CD3+ TCRgd+	22 (1-36)	10 (10-30)	24 (8-60)	^a^c^eP > 0.5

CD3+ CD103+	91 (58-96)	81 (75-87)	90 (80-99)	^a^c^eP > 0.5

CD3+ CD44+	95 (50-99)	94 (84-100)	94 (65-100)	^a^c^eP > 0.5

CD3+ CD28+	2 (1-11)	5 (1-10)	7 (1-9)	^a^c^eP > 0.5

CD3+ CD69+	97 (68-100)	99 (96-100)	96 (91-98)	^a^c^eP > 0.5

^aP > 0.5, Hp- vs control;

^cP > 0.5, Hp- vs Hp+;

^eP > 0.5, Hp+ vs control;

^bP < 0.01, Hp+ vs control.

Citation: Gargala G, Lecleire S, François A, Jacquot S, Déchelotte P, Ballet JJ, Favennec L, Ducrotté P. Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia. World J Gastroenterol 2007; 13(16): 2333-2338
URL: https://www.wjgnet.com/1007-9327/full/v13/i16/2333.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i16.2333