Hypermethylation and aberrant expression of Wnt antagonist secreted frizzled-related protein 1 in gastric cancer

Table 1 Hypermethylation and expression loss of SFRP1 in primary gastric cancer and matched cancer adjacent tissue samples

	n	Hypermethylation (+)	Expression (-)
Gastric cancer	52	23	17
Adjacent tissue	52	8	6
P		χ2 = 10.34, P < 0.01	χ2 = 6.75, P < 0.01

Table 2 Correlation of SFRP1 expression with SFRP1 hyperme-thylation and clinical pathologic patient data

Variable	Categorisation	n	SFRP1 (-)	P
Sex	Male	34	11	0.24
	Female	18	6
Age at diagnosis	> 50	30	12	0.10
(yr)	≤ 50	22	5
Tumor stage1	T1 + T2	25	4	0.01
	T3 + T4	27	13
Lymph node status	N0 + N1	36	8	0.02
	N2 + N3	16	9
Histological type	Diffused	31	12	0.13
	Intestinal	21	5
Methylation status	Methylated	28	13	0.02
	Unmethylated	24	4

¹According to UICC: TNM classification of malignant tumors.