Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations

Table 1 CYP2B6 genotypes in four study populations

A	Lahu (n = 216)	Wa (n = 202)	Bulang (n = 198)	Hong Kong (n = 398)
Allelic frequency
allele	% (95% CI)	% (95% CI)	% (95% CI)	% (95% CI)
64C > T	6.5 (3.2-9.8)	6.4 (3.1-9.8)	11.6 (7.2-16.1)	11.6 (8.4-14.7)
516G > T	31.5 (25.3-37.7)	40.1 (33.3-46.9)	29.3 (23.0-35.6)	35.9 (31.2-40.6)
B	Lahu (n = 108)	Wa (n = 101)	Bulang (n = 99)	Hong Kong (n = 199)
Genotype frequency
Genotype	% (95% CI)	% (95% CI)	% (95% CI)	% (95% CI)
64 CC	89.8 (84.1-95.5)	91.1 (85.5-96.6)	82.8 (75.4-90.3)	81.9 (76.6-87.3)
CT	7.4 (2.5-12.3)	5 (0.7-9.2)	11.1 (4.9-17.3)	13.1 (8.4-17.7)
TT	2.8 (0-5.9)	4 (0.2-7.8)	6.1 (1.4-10.8)	5 (2.0-8.1)
516 GG	44.4 (35.1-53.8)	35.6 (26.3-45.0)	50.5 (40.7-60.4)	51.3 (44.3-58.2)
GT	48.1 (38.7-57.6)	48.5 (38.8-58.3)	40.4 (30.7-50.1)	25.6 (19.6-31.7)
TT	7.4b (2.5-12.3)	15.8 (8.7-23.0)	9.1d (3.4-14.8)	23.1 (17.3-29.0)

^bP < 0.01, Hong Kong Chinese vs Lahu, Chi-square test;

^dP < 0.01, Hong Kong Chinese vs Bulang, Chi-square test.

Table 2 Comparison of allele 516G > T frequency between ethnic minority group and other ethnic populations

	Population	n	Frequency of allele516G > T
Southern Chinese (current study)		1014	0.345
Caucasian	Germany[6]	242	0.252a
	Germany[6]	1146	0.26a
	American[7]	86	0.22a
	Switzerland[8]	418	0.24a
	Canadian[9]	354	0.254a
	European-American[3]	178	0.224a
	United Kingdom[10]	270	0.281a
	Germany[4]	430	0.286
African	African-American[7]	58	0.28
	African-American[11]	90	0.278
	African-American[3]	100	0.38
	African-Canadian[9]	246	0.329
	Ghanaians[11]	82	0.488a
Hispanics	Spanish[12]	200	0.265a
	Hispanic-American[7]	14	0.43
	Hispanic-American[3]	30	0.266
	Hispanic-Canadian[9]	122	0.328
Asian	Japanese[13]	530	0.16a
	Japanese[11]	90	0.144a
	Japanese[14]	176	0.2a
	Korean[11]	92	0.152a
	Taiwan[11]	92	0.141a
	Han Chinese[15]	386	0.21a
	Hong Kong[16]	152	0.43a

n: Total number of alleles.

^aP < 0.05, Southern Chinese vs other ethnic population, Chi-square test.