Increased intestinal permeability in pathogenesis and progress of nonalcoholic steatohepatitis in rats

Table 1 Change of body, hepatic and serum lipid parameters in rats

Time(wk)	Group	Number	Weight	Hepaticindex (%)	TG (mmol/L)	TCh (mmol/L)	Degree of HepaticSteatosis				HAI mark
							-	+	++	+++
8	Control	12	307.58 ± 17.04	2.64 ± 0.09	0.51 ± 0.07	1.62 ± 0.16	12	0	0	0	0.67 ± 0.33
	Model	12	404.50 ± 13.18a	3.88 ± 0.53a	0.35 ± 0.05b	2.49 ± 0.36c	0	3	6	3	0.68 ± 0.27
12	Control	11	411.05 ± 16.84	2.81 ± 0.09	0.48 ± 0.10	1.38 ± 0.24	11	0	0	0	0.71 ± 0.12
	Model	6	506.16 ± 15.99a	4.58 ± 0.07a	0.49 ± 0.10	6.20 ± 2.14d,e,f	0	0	2	4	3.95 ± 0.83h,i
16	Control	11	453.55 ± 49.11	2.77 ± 0.12	0.51 ± 0.07	1.96 ± 0.45	11	0	0	0	0.69 ± 0.15
	Model	9	554.22 ± 28.37a	4.74 ± 0.13a	0.47 ± 0.10	2.93 ± 0.55g	0	0	1	9	5.25 ± 1.39h,j

Values are expressed as mean ± SD. a: P < 0.001 vs corresponding control group; b: t = 6.31, P < 0.001, vs control group at the 8^th wk; c: t = 7.67, P < 0.001, vs control group at the 8^th wk; d: t = 5.49, P = 0.003, vs control group at the 12^th wk; e: t = 3.60, P = 0.012, vs model group at the 16^th wk; f: t = 4.21, P = 0.008, vs model group at the 8^th wk; g: t = 3.53, P = 0.002, vs control group at the 16^th wk; h: P < 0.05, vs control group at the same stage of time; i: P < 0.05, vs model group at the 8^th wk; j: P < 0.05, vs model group at the 12^th wk.

Table 2 Change of hepatic function and intestinal permeability in rats

Time(wk)	Group	Number	ALT (mmol/L)	AST (mmol/L)	ALB (g/L)	D-lactate(mmol/L)	DAO (U/L)
8	Control	12	54.75 ± 7.05	200.33 ± 14.49	30.39 ± 2.33	0.19 ± 0.04	0.74 ± 0.11
	Model	12	125.75 ± 34.21a	270.91 ± 45.38d	26.91 ± 2.37g	0.36 ± 0.11h	0.77 ± 0.09
12	Control	11	56.73 ± 8.46	215.64 ± 31.53	31.09 ± 1.30	0.17 ± 0.03	0.65 ± 0.15
	Model	6	149.67 ± 30.81b	311.33 ± 53.33e	29.83 ± 1.72	0.54 ± 0.04i	0.92 ± 0.10k
16	Control	11	51.59 ± 7.54	195.10 ± 18.72	29.12 ± 2.51	0.20 ± 0.05	0.77 ± 0.17
	Model	9	166.56 ± 43.53c	314.22 ± 54.41f	28.98 ± 2.10	0.86 ± 0.12j	1.28 ± 0.19l

Values are expressed as mean ± SD. a: t = 7.04, P < 0.001, vs control group at the 8^th wk; b: t = 7.24, P < 0.001, vs control group at the 12^th wk; c: t = 7.83, P < 0.001, vs control group at the 16^th wk; d: t = 5.13, P < 0.001, vs control group at the 8^th wk; e: t = 4.70, P < 0.001, vs control group at the 12^th wk; f: t = 6.82, P < 0.001, vs control group at the 16^th wk; g: t = 5.24, P < 0.001, vs control group at the 8^th wk.; h: t = 5.50, P < 0.001, vs control group at the 8^th wk ; i: t = 9.70, P < 0.001, vs control group at the 12^th wk; j: t = 7.22, P < 0.001, vs control group at the 16^th wk; k: t = 3.91, P = 0.001, vs control group at the 12^th wk; l: t = 6.27, P < 0.001, vs control group at the 16^th wk.